Differential expression of insulin-like growth factor 1 in human primary liver cancer.

Yasuharu Ikeda, Kiyoshi Kajiyama, Yo Ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Masaru Morita, Eiji Oki, Hiroshi Saeki, Taketoshi Suehiro, Kohshi Mimori, Keishi Sugimachi, Ken Shirabe, Yoshihiko Maehara

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.

本文言語英語
ページ(範囲)334-338
ページ数5
ジャーナルUnknown Journal
104
10
出版ステータス出版済み - 10 2013

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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