Differential FDG accumulation associated with GLUT-1 expression in a patient with lymphoma

Hirofumi Koga, Yoshio Matsuo, Masayuki Sasaki, Makoto Nakagawa, Koichiro Kaneko, Kazutaka Hayashi, Yasuo Kuwabara, Hiroshi Honda

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

We herein report a case of malignant lymphoma that showed differential FDG accumulation associated with the degree of glucose transporter 1 (GLUT-1) expression. For clinical staging purpose, FDG-PET was performed on a 47-year-old male who had been diagnosed to have malignant lymphoma, diffuse medium B-cell type. Although an X-ray CT showed multiple and bulky lymphadenopathy including bilateral submandibular, deep cervical, supraclavicular, axillar, hilar, mesenteric and paraaortic regions, FDG-PET showed a high accumulation only in the bilateral submandibular and deep cervical region. An immunohistochemical analysis demonstrated a high GLUT-1 expression in the right cervical lymph node, which showed a high FDG uptake. On the other hand, a bone marrow specimen with diffuse lymphoma cell involvement indicated showed no FDG accumulation and also revealed a negative GLUT-1 expression. This case suggests that the differential FDG accumulation shown by lesions is associated with the degree of GLUT-1 expression in patients with lymphoma.

本文言語英語
ページ(範囲)327-331
ページ数5
ジャーナルAnnals of Nuclear Medicine
17
4
DOI
出版ステータス出版済み - 6 2003

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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