Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder

Keitaro Murayama, Tomohiro Nakao, Hirokuni Sanematsu, Kayo Okada, Takashi Yoshiura, Mayumi Tomita, Yusuke Masuda, Kayoko Isomura, Akiko Nakagawa, Shigenobu Kanba

研究成果: Contribution to journalArticle査読

27 被引用数 (Scopus)

抄録

Obsessive-compulsive disorder (OCD) is clinically heterogeneous. The aim of this study was to investigate differential neural responses to a symptom provocation task in drug-free patients who have predominantly aggression/checking symptoms (Checkers) and patients with contamination/washing symptoms (Washers). We compared the Checkers (n = 10) and the Washers (n = 12) separately to normal controls during the symptom provocation tasks using fMRI (functional magnetic resonance imaging). Moreover, we performed correlative analysis in each OCD group between brain activation and symptom severity. The Checkers showed hypoactivation in the left caudate and left anterior cingulate cortex (ACC) compared to the normal controls and a positive correlation between activated brain areas and symptom severity in the left ACC. The Washers showed hyperactivation in several bilateral cortico-cerebellar regions and a positive correlation between symptom severity and the bilateral fronto-temporal gyrus. We suggest that the caudate and ACC are associated with checking rituals and that large cortical brain regions are related to washing rituals.

本文言語英語
ページ(範囲)160-166
ページ数7
ジャーナルProgress in Neuro-Psychopharmacology and Biological Psychiatry
40
1
DOI
出版ステータス出版済み - 1 2013

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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