Differential nociceptive responses in mice lacking the α1B subunit of N-type Ca2+ channels

Shinji Hatakeyama, Minoru Wakamori, Mitsuhiro Ino, Norimasa Miyamoto, Eiki Takahashi, Takashi Yoshinaga, Kohei Sawada, Keiji Imoto, Isao Tanaka, Toshihiro Yoshizawa, Yukio Nishizawa, Yasuo Mori, Tetsuhiro Niidome, Shin'ich Shoji

研究成果: Contribution to journalArticle査読

122 被引用数 (Scopus)

抄録

The role of N-type Ca2+ channels in nociceptive transmission was examined in genetically engineered mice lacking the α1B subunit of N-type channels and in their heterozygote and wild-type littermates. In α1B-deficient mice, N-type channel activities in dorsal root ganglion neurons and spinal synaptoneurosomes were eliminated without compensation by other types of voltage-dependent Ca2+ channels. The α1B-deficient mice showed a diminution in the phase 2 nociceptive responses more extensively than in the phase I-nociceptive responses of the formalin test. The α1B-deficient mice exhibited significantly increased thermal nociceptive thresholds in the hot plate test, but failed to increase mechanical nociceptive thresholds in the tail pinch test. These results suggest a crucial role of N-type channels in nociceptive transmission, especially for persistent pain like phase 2 of the formalin test and for nociception induced by thermal stimuli.

本文言語英語
ページ(範囲)2423-2427
ページ数5
ジャーナルNeuroReport
12
11
DOI
出版ステータス出版済み - 8 8 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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