Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats

Shinobu Yasuo, Miwa Watanabe, Masayuki Iigo, Takahiro J. Nakamura, Tsuyoshi Watanabe, Tsuyoshi Takagi, Hiroko Ono, Shizufumi Ebihara, Takashi Yoshimura

研究成果: Contribution to journalArticle査読

47 被引用数 (Scopus)

抄録

The molecular basis of seasonal or nonseasonal breeding remains unknown. Although laboratory rats are generally regarded as photoperiod-insensitive species, the testicular weight of the Fischer 344 (F344) strain responds to photoperiod. Recently, it was clarified that photoperiodic regulation of type 2 iodothyronine deiodinase (Dio2) in the mediobasal hypothalamus (MBH) is critical in photoperiodic gonadal regulation. Strain-dependent differences in photoperiod sensitivity may now provide the opportunity to address the regulatory mechanism of seasonality by studying Dio2 expression. Therefore, in the present study, we examined the effect of photoperiod on Dio2 expression in photoperiod-sensitive F344 and photoperiod-insensitive Wistar rats. A statistically significant difference was observed between short and long days in terms of testicular weight and Dio2 expression in the F344 strain, while no difference was observed in the Wistar strain. These results suggest that differential responses of the Dio2 gene to photoperiod may determine the strain-dependent differences in photoperiod sensitivity in laboratory rats.

本文言語英語
ページ(範囲)R1315-R1319
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
292
3
DOI
出版ステータス出版済み - 3 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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