Differentiation of circulating endothelial progenitor cells to a cardiomyogenic phenotype depends on E-cadherin

Masamichi Koyanagi, Carmen Urbich, Emmanouil Chavakis, Jörg Hoffmann, Stefan Rupp, Cornel Badorff, Andreas M. Zeiher, Anna Starzinski-Powitz, Judith Haendeler, Stefanie Dimmeler

研究成果: ジャーナルへの寄稿学術誌査読

43 被引用数 (Scopus)

抄録

Progenitor cells may contribute to cardiac regeneration. Here, we investigated the role of cadherins and integrins for differentiation of human adult circulating endothelial progenitor cells (EPCs) into cardiomyocytes (CM) in a co-culture system. N- and E-cadherin were expressed in EPCs and were localized at the interface between EPCs and CM. Incubation of a blocking antibody against E-cadherin reduced the expression of CM marker protein in EPCs. Blocking antibodies against N- or P-cadherin or the β1- and β2-integrins were not effective. These data suggested that cell-to-cell communication mediated by E-cadherin contributes to the acquirement of a cardiomyogenic phenotype of human endothelial progenitor cells.

本文言語英語
ページ(範囲)6060-6066
ページ数7
ジャーナルFEBS Letters
579
27
DOI
出版ステータス出版済み - 11月 7 2005
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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