Differentiation of periodontal ligament stem/progenitor cells: Roles of TGF-β1

Hidefumi Maeda, Shinsuke Fujii, Satoshi Monnouchi, Naohisa Wada, Akifumi Akamine

研究成果: Chapter in Book/Report/Conference proceedingChapter

1 被引用数 (Scopus)


Tooth loss provokes loss of occlusal function, resulting in a decreased quality of life. Tooth loss is related primarily to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases, or irreversible trauma. Periodontal ligament (PDL) is a central tissue in periodontium and contains stem/progenitor cells that are believed to have the potential to regenerate periodontium, including PDL tissue. For this reason, we and other groups have focused on such undifferentiated cells to elucidate their applicable potentials for PDL regenerative medicine based on cell-based tissue engineering. However, how their differentiation is controlled remains unclear. We recently suggested that transforming growth factor-beta 1 is a candidate factor for regulation of fibroblastic differentiation of stem/progenitor cells in PDL tissue.

ホスト出版物のタイトルStem Cells and Cancer Stem Cells, Volume 4
ホスト出版物のサブタイトルTherapeutic Applications in Disease and Injury
出版社Springer Netherlands
出版ステータス出版済み - 1 1 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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