Diffuse alveolar damage after ZD1839 therapy in a patient with non-small cell lung cancer

Isamu Okamoto, Kazuhiko Fujii, Mitsuhiro Matsumoto, Yasuhiro Terasaki, Nanae Kihara, Hirotsugu Kohrogi, Moritaka Suga

研究成果: Contribution to journalArticle査読

58 被引用数 (Scopus)

抄録

ZD1839 is an orally active inhibitor selective for the epidermal growth factor receptor tyrosine kinase and has shown promise in the treatment of non-small cell lung cancer (NSCLC). We now present a case of diffuse alveolar damage (DAD) that developed in a 67-year-old man treated with ZD1839. On day 8 of ZD1839 administration, the patient complained of dyspnea and a new-ground glass opacity was apparent on a chest X-ray and computed tomography scan. Despite high-dose steroid therapy, the patient died 13 days after the first administration of ZD1839. Postmortem analysis of lung tissue revealed a pattern of DAD. No evidence of infection or of other specific etiologies was apparent. This case is the first reported of respiratory failure after ZD1839 treatment in a patient with NSCLC. Physicians should therefore be aware of the potential pulmonary toxicity of ZD1839.

本文言語英語
ページ(範囲)339-342
ページ数4
ジャーナルLung Cancer
40
3
DOI
出版ステータス出版済み - 6 1 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 呼吸器内科
  • 癌研究

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