Diffusion of nitrous oxide through endotracheal tube cuffs

Shigeki Fujiwara, Akiko Noguchi, Yuichiro Nakamura, Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama

研究成果: ジャーナルへの寄稿記事

抄録

During general anesthesia using nitrous oxide (N 2 O), N 2 O diffuses into the tracheal tube cuff and increases cuff pressure, potentially causing tissue damage in the trachea. However, the permeability of the tube cuff to N 2 O flowing into the cuff is unknown. Here, we examined decrease in cuff pressure and N 2 O permeability of the tracheal tube cuff. Two tracheal tubes, i.e., Portex Blue Line Profile, Soft-Seal Cuff (SPN) and Mallinckrodt Nasal RAE Tracheal Tube Cuffed, Murphy Eye (MRN), were examined. Six gas samples (air, oxygen, 70% N 2 O in oxygen, 50% N 2 O in oxygen, 30% N 2 O in oxygen, and a mixture of 60% N 2 O in oxygen to air [4:3]) were prepared and used to inflate both cuffs at a pressure of 30 cmH 2 O. Cuff pressures were recorded at every 5 min. After inflation with air, cuff pressures reached 26.8 ± 1.9 and 30.0 cmH 2 O for MRN and SPN, respectively, within 60 min. Inflation with 70% N 2 O dramatically decreased cuff pressures (3.2 ± 0.4 and 5.2 ± 1.1 cmH 2 O, respectively). The rate of pressure decrease was dependent on the concentration of N 2 O and was more rapid for MRN than SPN. Inflation with the mixture gas decreased the pressure to 14.8 ± 2.7 and 17.4 ± 3.8 cmH 2 O for MRN and SPN, respectively, within 60 min. Here, we provided the first analysis of deflating cuff pressures, which may help to predict patterns for cuff pressure deflation in clinical practice. This study model may be beneficial for the study of ventilator-associated pneumonia.

元の言語英語
ページ(範囲)40-45
ページ数6
ジャーナルBiomedical Research (India)
27
発行部数1
出版物ステータス出版済み - 1 1 2016

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Nitrous Oxide
Pressure
Oxygen
Economic Inflation
Permeability
Gases
Air
Air Pressure
Ventilator-Associated Pneumonia
Trachea
Nose
General Anesthesia
Gas mixtures
Seals
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Diffusion of nitrous oxide through endotracheal tube cuffs. / Fujiwara, Shigeki; Noguchi, Akiko; Nakamura, Yuichiro; Tsukamoto, Masanori; Hitosugi, Takashi; Yokoyama, Takeshi.

:: Biomedical Research (India), 巻 27, 番号 1, 01.01.2016, p. 40-45.

研究成果: ジャーナルへの寄稿記事

Fujiwara, Shigeki ; Noguchi, Akiko ; Nakamura, Yuichiro ; Tsukamoto, Masanori ; Hitosugi, Takashi ; Yokoyama, Takeshi. / Diffusion of nitrous oxide through endotracheal tube cuffs. :: Biomedical Research (India). 2016 ; 巻 27, 番号 1. pp. 40-45.
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abstract = "During general anesthesia using nitrous oxide (N 2 O), N 2 O diffuses into the tracheal tube cuff and increases cuff pressure, potentially causing tissue damage in the trachea. However, the permeability of the tube cuff to N 2 O flowing into the cuff is unknown. Here, we examined decrease in cuff pressure and N 2 O permeability of the tracheal tube cuff. Two tracheal tubes, i.e., Portex Blue Line Profile, Soft-Seal Cuff (SPN) and Mallinckrodt Nasal RAE Tracheal Tube Cuffed, Murphy Eye (MRN), were examined. Six gas samples (air, oxygen, 70{\%} N 2 O in oxygen, 50{\%} N 2 O in oxygen, 30{\%} N 2 O in oxygen, and a mixture of 60{\%} N 2 O in oxygen to air [4:3]) were prepared and used to inflate both cuffs at a pressure of 30 cmH 2 O. Cuff pressures were recorded at every 5 min. After inflation with air, cuff pressures reached 26.8 ± 1.9 and 30.0 cmH 2 O for MRN and SPN, respectively, within 60 min. Inflation with 70{\%} N 2 O dramatically decreased cuff pressures (3.2 ± 0.4 and 5.2 ± 1.1 cmH 2 O, respectively). The rate of pressure decrease was dependent on the concentration of N 2 O and was more rapid for MRN than SPN. Inflation with the mixture gas decreased the pressure to 14.8 ± 2.7 and 17.4 ± 3.8 cmH 2 O for MRN and SPN, respectively, within 60 min. Here, we provided the first analysis of deflating cuff pressures, which may help to predict patterns for cuff pressure deflation in clinical practice. This study model may be beneficial for the study of ventilator-associated pneumonia.",
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