Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2

Chikara Meno, Jun Takeuchi, Rui Sakuma, Kazuko Koshiba-Takeuchi, Sachiko Ohishi, Yukio Saijoh, Jun Ichi Miyazaki, Peter Ten Dijke, Toshihiko Ogura, Hiroshi Hamada

研究成果: Contribution to journalArticle査読

104 被引用数 (Scopus)

抄録

The role of Lefty2 in left-right patterning was investigated by analysis of mutant mice that lack asymmetric expression of lefty2. These animals exhibited various situs defects including left isomerism. The asymmetric expression of nodal was prolonged and the expression of Pitx2 was upregulated in the mutant embryos. The absence of Lefty2 conferred on Nodal the ability to diffuse over a long distance. Thus, Nodal-responsive genes, including Pitx2, that are normally expressed on the left side were expressed bilaterally in the mutant embryos, even though nodal expression was confined to the left side. These results suggest that Nodal is a long-range signaling molecule but that its range of action is normally limited by the feedback inhibitor Lefty2.

本文言語英語
ページ(範囲)127-138
ページ数12
ジャーナルDevelopmental Cell
1
1
DOI
出版ステータス出版済み - 7 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 生化学、遺伝学、分子生物学(全般)
  • 発生生物学
  • 細胞生物学

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