Difluoro-C4′-oxidized abasic site for efficient amine modification in biological systems

Bo Yang, Akiko Jinnouchi, Hiroshi Suemune, Mariko Aso

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

An oligodeoxynucleotide (ODN) containing a 2′,2′-difluorinated analogue of a C4′-oxidized abasic site (C4′-OAS) was designed for the amine modification of biomolecules that interact with nucleic acids. In contrast to the parent C4′-OAS, which yielded amine-modified products accompanied by DNA strand scission, the ODN containing the difluoro C4′-OAS efficiently yielded products carrying ODNs. The amine modification proceeded without additional reagents being required and might be applicable to reactions in biological systems.

元の言語英語
ページ(範囲)5852-5855
ページ数4
ジャーナルOrganic Letters
14
発行部数23
DOI
出版物ステータス出版済み - 12 7 2012

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Biological systems
Amines
amines
Oligodeoxyribonucleotides
Biomolecules
nucleic acids
products
strands
Nucleic Acids
reagents
cleavage
deoxyribonucleic acid
analogs
DNA

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

これを引用

Difluoro-C4′-oxidized abasic site for efficient amine modification in biological systems. / Yang, Bo; Jinnouchi, Akiko; Suemune, Hiroshi; Aso, Mariko.

:: Organic Letters, 巻 14, 番号 23, 07.12.2012, p. 5852-5855.

研究成果: ジャーナルへの寄稿記事

Yang, Bo ; Jinnouchi, Akiko ; Suemune, Hiroshi ; Aso, Mariko. / Difluoro-C4′-oxidized abasic site for efficient amine modification in biological systems. :: Organic Letters. 2012 ; 巻 14, 番号 23. pp. 5852-5855.
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