Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity

Toyohi Isse, Tsunehiro Oyama, Kyoko Kitagawa, Koji Matsuno, Akiko Matsumoto, Akira Yoshida, Keiko Nakayama, Keiichi Nakayama, Toshihiro Kawamoto

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

抄録

Aldehyde dehydrogenase (ALDH) 2 plays a major role in the detoxification of aldehyde and is known to be responsible for alcohol preference. A diminished enzyme activity due to mutation of the Aldh2 gene is associated with high alcohol sensitivity and a low alcohol tolerance in humans. The genomic background distinguishing an alcohol preference and avoidance in various inbred mouse strains is not clear. We created Aldh2-negative mice by transgenic knockout of the Aldh2 gene into the high alcohol preference C57BL/6 background. The Aldh2 gene targeting (Aldh-/-) mice exhibited an alcohol avoidance characteristic. After free-choice ethanol and water drinking, brain and liver acetaldehyde concentrations of Aldh2-/- mice were almost equal to those of wild-type (Aldh2+/+) mice although the Aldh2-/- mice drank less ethanol than the Aldh2+/+ mice. This result indicates that a direct effect of the Aldh2 genotype plays an important role on alcohol preference and acetaldehyde concentration in the brain is correlated with alcohol avoidance. This highlights the potential benefits of alcoholism and alcohol-related disease research in the animal model of ALDH2 alleles.

元の言語英語
ページ(範囲)621-626
ページ数6
ジャーナルPharmacogenetics
12
発行部数8
DOI
出版物ステータス出版済み - 11 1 2002

Fingerprint

Aldehyde Dehydrogenase
Transgenic Mice
Alcohols
Acetaldehyde
Ethanol
Gene Knockout Techniques
Inbred Strains Mice
Gene Targeting
Brain
Knockout Mice
Aldehydes
Drinking Water
Alcoholism
Animal Models
Alleles
Genotype
Mutation
Liver

All Science Journal Classification (ASJC) codes

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

これを引用

Isse, T., Oyama, T., Kitagawa, K., Matsuno, K., Matsumoto, A., Yoshida, A., ... Kawamoto, T. (2002). Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics, 12(8), 621-626. https://doi.org/10.1097/00008571-200211000-00006

Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. / Isse, Toyohi; Oyama, Tsunehiro; Kitagawa, Kyoko; Matsuno, Koji; Matsumoto, Akiko; Yoshida, Akira; Nakayama, Keiko; Nakayama, Keiichi; Kawamoto, Toshihiro.

:: Pharmacogenetics, 巻 12, 番号 8, 01.11.2002, p. 621-626.

研究成果: ジャーナルへの寄稿記事

Isse, T, Oyama, T, Kitagawa, K, Matsuno, K, Matsumoto, A, Yoshida, A, Nakayama, K, Nakayama, K & Kawamoto, T 2002, 'Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity', Pharmacogenetics, 巻. 12, 番号 8, pp. 621-626. https://doi.org/10.1097/00008571-200211000-00006
Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A その他. Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics. 2002 11 1;12(8):621-626. https://doi.org/10.1097/00008571-200211000-00006
Isse, Toyohi ; Oyama, Tsunehiro ; Kitagawa, Kyoko ; Matsuno, Koji ; Matsumoto, Akiko ; Yoshida, Akira ; Nakayama, Keiko ; Nakayama, Keiichi ; Kawamoto, Toshihiro. / Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. :: Pharmacogenetics. 2002 ; 巻 12, 番号 8. pp. 621-626.
@article{6c50edb699394ca29cce30191bb8e72c,
title = "Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity",
abstract = "Aldehyde dehydrogenase (ALDH) 2 plays a major role in the detoxification of aldehyde and is known to be responsible for alcohol preference. A diminished enzyme activity due to mutation of the Aldh2 gene is associated with high alcohol sensitivity and a low alcohol tolerance in humans. The genomic background distinguishing an alcohol preference and avoidance in various inbred mouse strains is not clear. We created Aldh2-negative mice by transgenic knockout of the Aldh2 gene into the high alcohol preference C57BL/6 background. The Aldh2 gene targeting (Aldh-/-) mice exhibited an alcohol avoidance characteristic. After free-choice ethanol and water drinking, brain and liver acetaldehyde concentrations of Aldh2-/- mice were almost equal to those of wild-type (Aldh2+/+) mice although the Aldh2-/- mice drank less ethanol than the Aldh2+/+ mice. This result indicates that a direct effect of the Aldh2 genotype plays an important role on alcohol preference and acetaldehyde concentration in the brain is correlated with alcohol avoidance. This highlights the potential benefits of alcoholism and alcohol-related disease research in the animal model of ALDH2 alleles.",
author = "Toyohi Isse and Tsunehiro Oyama and Kyoko Kitagawa and Koji Matsuno and Akiko Matsumoto and Akira Yoshida and Keiko Nakayama and Keiichi Nakayama and Toshihiro Kawamoto",
year = "2002",
month = "11",
day = "1",
doi = "10.1097/00008571-200211000-00006",
language = "English",
volume = "12",
pages = "621--626",
journal = "Pharmacogenetics and Genomics",
issn = "1744-6872",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity

AU - Isse, Toyohi

AU - Oyama, Tsunehiro

AU - Kitagawa, Kyoko

AU - Matsuno, Koji

AU - Matsumoto, Akiko

AU - Yoshida, Akira

AU - Nakayama, Keiko

AU - Nakayama, Keiichi

AU - Kawamoto, Toshihiro

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Aldehyde dehydrogenase (ALDH) 2 plays a major role in the detoxification of aldehyde and is known to be responsible for alcohol preference. A diminished enzyme activity due to mutation of the Aldh2 gene is associated with high alcohol sensitivity and a low alcohol tolerance in humans. The genomic background distinguishing an alcohol preference and avoidance in various inbred mouse strains is not clear. We created Aldh2-negative mice by transgenic knockout of the Aldh2 gene into the high alcohol preference C57BL/6 background. The Aldh2 gene targeting (Aldh-/-) mice exhibited an alcohol avoidance characteristic. After free-choice ethanol and water drinking, brain and liver acetaldehyde concentrations of Aldh2-/- mice were almost equal to those of wild-type (Aldh2+/+) mice although the Aldh2-/- mice drank less ethanol than the Aldh2+/+ mice. This result indicates that a direct effect of the Aldh2 genotype plays an important role on alcohol preference and acetaldehyde concentration in the brain is correlated with alcohol avoidance. This highlights the potential benefits of alcoholism and alcohol-related disease research in the animal model of ALDH2 alleles.

AB - Aldehyde dehydrogenase (ALDH) 2 plays a major role in the detoxification of aldehyde and is known to be responsible for alcohol preference. A diminished enzyme activity due to mutation of the Aldh2 gene is associated with high alcohol sensitivity and a low alcohol tolerance in humans. The genomic background distinguishing an alcohol preference and avoidance in various inbred mouse strains is not clear. We created Aldh2-negative mice by transgenic knockout of the Aldh2 gene into the high alcohol preference C57BL/6 background. The Aldh2 gene targeting (Aldh-/-) mice exhibited an alcohol avoidance characteristic. After free-choice ethanol and water drinking, brain and liver acetaldehyde concentrations of Aldh2-/- mice were almost equal to those of wild-type (Aldh2+/+) mice although the Aldh2-/- mice drank less ethanol than the Aldh2+/+ mice. This result indicates that a direct effect of the Aldh2 genotype plays an important role on alcohol preference and acetaldehyde concentration in the brain is correlated with alcohol avoidance. This highlights the potential benefits of alcoholism and alcohol-related disease research in the animal model of ALDH2 alleles.

UR - http://www.scopus.com/inward/record.url?scp=0036867509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036867509&partnerID=8YFLogxK

U2 - 10.1097/00008571-200211000-00006

DO - 10.1097/00008571-200211000-00006

M3 - Article

C2 - 12439222

AN - SCOPUS:0036867509

VL - 12

SP - 621

EP - 626

JO - Pharmacogenetics and Genomics

JF - Pharmacogenetics and Genomics

SN - 1744-6872

IS - 8

ER -