Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers

Eriko Tokunaga, Yoshihiko Maehara, Eiji Oki, Kaoru Kitamura, Yoshihiro Kakeji, Shinji Ohno, Keizo Sugimachi

研究成果: Contribution to journalArticle査読

52 被引用数 (Scopus)

抄録

p33(ING1) is a novel candidate tumor suppressor and its overexpression induces growth arrest or apoptosis in different cell lines. These functions of p33(ING1) depend largely on the activity of p53, and p53-dependent activation of the transcription from the p21/WAF1 promoter also requires p33(ING1). We examined the expression of ING1 mRNA in breast cancer cell lines and clinical breast cancer tissues, using quantitative RT-PCR and real time TaqMan(TM) technology. In breast cancer cell lines, ING1 mRNA was expressed at almost the same level. However, in a comparison between the cancer and matched normal tissues, a significant decrease in ING1 mRNA expression was found in 17 of 24 (70.8%) breast cancer tissues. We also examined the correlation between ING1 mRNA expression and p53 expression. There was a significant decrease of ING1 mRNA in nine of 15 tumors negative for p53 immunostaining, most of which were considered to have wild type p53. In these tumors, p53 may not function in case of a decreased expression of p33(ING1), and the lack of cell cycle regulation may correlate with the carcinogenesis and tumor progression. Copyright (C) 2000 Elsevier Science Ireland Ltd.

本文言語英語
ページ(範囲)15-22
ページ数8
ジャーナルCancer Letters
152
1
DOI
出版ステータス出版済み - 4 28 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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