抄録
Two possible mechanisms for dioxygen cleavage on non-heme diiron enzyme models are studied with an approximate molecular orbital method, the extended Huckel method. Diiron peroxo model complexes with different μ-η1:η1-O2 and μ-η2:η2-O2 binding modes are distorted to corresponding dioxo complexes along an assumed O-O bond cleavage reaction coordinate. Fragment molecular orbital (FMO) and Walsh diagram analyses clarify the bonding and orbital interactions. While the π(g)* orbitals of O2 are initially occupied by two electrons, in the first dioxygen binding step two other electrons are effectively transferred from the 't(2g)' block to O2 to form O22-. To cleave the dioxygen O-O bond, it is necessary further to fill the σ(u)* orbital (high lying and unoccupied in the peroxide). The computations suggest that the μ-ν1:ν1-O2 mode is more effective for electron transfer from the d-block orbitals to the σ(u)*. Our calculations indicate that a C(3v)- or D(2d)-distorted methane can be activated if a coordinatively unsaturated iron, which has been proposed to exist in the diamond Fe2(μ- O)2 core of intermediate Q of methane monooxygenase, is generated. The complex is suggested to include a five-coordinate carbon species with an Fe- CH4 bond. We propose possible concerted reaction pathways for the conversion of methane to methanol on the supposed diiron active site of methane monooxygenase. Inversion at a five-coordinate carbon species is suggested to reasonably occur in an initially formed complex of methane and a model of intermediate Q, leading to inversion of stereochemistry at a labeled carbon center.
本文言語 | 英語 |
---|---|
ページ(範囲) | 12311-12321 |
ページ数 | 11 |
ジャーナル | Journal of the American Chemical Society |
巻 | 119 |
号 | 50 |
DOI | |
出版ステータス | 出版済み - 12月 17 1997 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 触媒
- 化学 (全般)
- 生化学
- コロイド化学および表面化学