Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides

Toru Deguchi, Hai Long Xin, Hiroyuki Morimoto, Takashi Ohshima

研究成果: ジャーナルへの寄稿学術誌査読

67 被引用数 (Scopus)

抄録

Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chemistry, and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, we report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcohols, affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.

本文言語英語
ページ(範囲)3157-3161
ページ数5
ジャーナルACS Catalysis
7
5
DOI
出版ステータス出版済み - 5月 5 2017

!!!All Science Journal Classification (ASJC) codes

  • 触媒
  • 化学 (全般)

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