Direct catalytic asymmetric intramolecular conjugate addition of thioamide to α,β-unsaturated esters

Yuta Suzuki, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Contribution to journalArticle

21 引用 (Scopus)

抜粋

Proton transfer allows efficient access to optically active five- and six-membered ring systems bearing ester and thioamide functionalities in an anti fashion; these ring systems are amenable to differential functional group manipulation. Direct catalytic, asymmetric, intramolecular conjugate addition of thioamide to α,β-unsaturated esters is described. In situ generated Cu thioamide enolate, by catalytic deprotonation, underwent the conjugate addition/protonation, to achieve the complete transformation (see scheme).

元の言語英語
ページ(範囲)11998-12001
ページ数4
ジャーナルChemistry - A European Journal
17
発行部数43
DOI
出版物ステータス出版済み - 10 17 2011
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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