Direct Catalytic Enantio- And Diastereoselective Aldol Reaction Using a Zn-Zn-Linked-BINOL Complex: A Practical Synthesis of syn-1,2-Diols

Naoya Kumagai, Shigeki Matsunaga, Naoki Yoshikawa, Takashi Ohshima, Masakatsu Shibasaki

研究成果: Contribution to journalArticle査読

110 被引用数 (Scopus)

抄録

matrix presented The direct catalytic enantio- and diastereoselective aldol reaction with 2-hydroxy-2′-methoxyacetophenone proceeded smoothly using as little as 1 mol % of a dinuclear zinc catalyst, Zn-Zn-linked-BINOL complex 2, to afford α,β-dihydroxy ketones in a highly syn-selective manner (up to synlanti 97/3) and in excellent yields (up to 95%) and ees (up to 99%). Efficient transformations of the α,β-dihydroxy ketone into an α,β-dihydroxy ester and an α,β-dihydroxy amide via regioselective rearrangements are also described.

本文言語英語
ページ(範囲)1539-1542
ページ数4
ジャーナルOrganic Letters
3
10
DOI
出版ステータス出版済み - 5 17 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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