Direct chemical derivatization of natural plant extract: Straightforward synthesis of natural plant-like hydantoin

Keisuke Tomohara, Tomohiro Ito, Naoto Hasegawa, Atsushi Kato, Isao Adachi

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

The direct chemical derivatization of natural plant extracts that would enable the straightforward synthesis of natural plant-like molecules seemed to be far from reality due primarily to the inherently complex chemical property of the extract. After model studies, the envisioned derivatization was realized under the rationally designed Bucherer-Bergs reaction conditions to afford unnatural hydantoin with tetrasubstituted carbon from the ethyl acetate extract of Curcuma zedoaria. The reaction proceeded with enough chemoselectivity to identify the desired product from the mixture by the reliable guidance of spectroscopic analyses.

本文言語英語
ページ(範囲)924-927
ページ数4
ジャーナルTetrahedron Letters
57
8
DOI
出版ステータス出版済み - 2 24 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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