Direct Correlation between Molecular Cross-linking and Macroscopic Mechanical Properties for Green Solids of Deoxyribonucleic Acids

Yuma Morimitsu, Hisao Matsuno, Noboru Ohta, Hiroshi Sekiguchi, Keiji Tanaka

    研究成果: Contribution to journalArticle査読

    4 被引用数 (Scopus)

    抄録

    Double-stranded deoxyribonucleic acids (DNAs) were intermolecularly cross-linked using 2,5-hexanedione under reductive amination conditions in aqueous phase. Cross-linking points between DNAs were directly observed by atomic force microscopy in conjunction with a conventional gel electrophoresis analysis. While DNA chains near cross-linking points were denatured, DNA chains not near cross-linking points maintained B-form double strands. A transparent and self-supported film of cross-linked DNA (DNA-c) was obtained by a simple solvent-casting method. The tensile properties of DNA-c films were much better than those of non-cross-linked DNA (DNA-n) films due to the presence of the cross-linking portions. Structural analyses based on wide-angle X-ray diffraction measurements revealed that the reorientation of DNA-c was remarkably restricted by the introduction of cross-linking points.

    本文言語英語
    ページ(範囲)1023-1027
    ページ数5
    ジャーナルChemNanoMat
    2
    11
    DOI
    出版ステータス出版済み - 11 2016

    All Science Journal Classification (ASJC) codes

    • Biomaterials
    • Renewable Energy, Sustainability and the Environment
    • Energy Engineering and Power Technology
    • Materials Chemistry

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