Direct guanylation of amino groups by cyanamide in water: Catalytic generation and activation of unsubstituted carbodiimide by scandium(iii) triflate

Kazuki Tsubokura, Takayuki Iwata, Misako Taichi, Almira Kurbangalieva, Koichi Fukase, Yoichi Nakao, Katsunori Tanaka

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

Guanylation proceeded efficiently upon treatment of the various amines with cyanamide in the presence of catalytic amounts of scandium(III) triflate under mild conditions. The method did not require the guanylation reagents to be preactivated, and the reaction proceeded efficiently in water. The method, therefore, has practical utility for substrates that dissolve only in aqueous solutions, for example, peptides or pharmacologically important compounds.

本文言語英語
ページ(範囲)1302-1306
ページ数5
ジャーナルSynlett
25
9
DOI
出版ステータス出版済み - 6 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 有機化学

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