Directing and Boosting of Cell Migration by the Entropic Force Gradient in Polymer Solution

Tatsuya Fukuyama, Ariko Fuke, Megumi Mochizuki, Ken Ichiro Kamei, Yusuke T. Maeda

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

Noncontact manipulation of nano/micromaterials presents a great challenge in fields ranging from biotechnology to nanotechnology. In this study we developed a new strategy for the manipulation of molecules and cells based on diffusiophoresis driven by a concentration gradient of a polymer solute. By using laser focusing in a microfluidic device, we created a sharp concentration gradient of poly(ethylene glycol) (PEG) in a solution of this polymer. Because diffusiophoresis essentially depends on solute gradients alone, PEG solute contrast resulted in trapping of DNA and eukaryotic cells with little material dependence. Furthermore, quantitative analysis revealed that the motility of migrating cells was enhanced with the PEG concentration, consistent with a theoretical model of boosted cell migration. Our results support that a solute contrast of polymer can exert an interfacial force gradient that physically propels objects and may have application for the manipulation of soft materials.

本文言語英語
ページ(範囲)12567-12572
ページ数6
ジャーナルLangmuir
31
46
DOI
出版ステータス出版済み - 10 23 2015

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

フィンガープリント 「Directing and Boosting of Cell Migration by the Entropic Force Gradient in Polymer Solution」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル