Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

Kei Ichi Nakayama, Keiko Nakayama, Izumi Negishi, Keisuke Kuida, Yoichi Shinkai, Marjorie C. Louie, Larry E. Fields, Phillip J. Lucas, Valerie Stewart, Frederick W. Alt, Dennis Y. Loh

研究成果: ジャーナルへの寄稿記事

352 引用 (Scopus)

抜粋

The bcl-2 proto-oncogene can prevent the death of many cell types. Mice were generated that were chimeric for the homozygous inactivation of bcl-2. Lymphocytes without Bcl-2 differentiated into phenotypically mature cells. However, in vitro, the mature T cells that lacked Bcl-2 had shorter life-spans and increased sensitivity to glucocorticoids and γ-irradiation. In contrast, stimulation of CD3 inhibited the death of these cells. T and B cells with no Bcl-2 disappeared from the bone marrow, thymus, and periphery by 4 weeks of age. Thus, Bcl-2 was dispensable for lymphocyte maturation, but was required for a stable immune system after birth.

元の言語英語
ページ(範囲)1584-1588
ページ数5
ジャーナルScience
261
発行部数5128
DOI
出版物ステータス出版済み - 1 1 1993
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • General

これを引用

Nakayama, K. I., Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M. C., ... Loh, D. Y. (1993). Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science, 261(5128), 1584-1588. https://doi.org/10.1126/science.8372353