Discovery of a novel flavivirus (Flaviviridae) from the horse fly, tabanus rufidens (Diptera: Tabanidae): The possible coevolutionary relationships between the classical insect-specific flaviviruses and host dipteran insects

Daisuke Kobayashi, Mamoru Watanabe, Astri Nur Faizah, Michael Amoa-Bosompem, Yukiko Higa, Yoshio Tsuda, Kyoko Sawabe, Haruhiko Isawa

研究成果: Contribution to journalArticle査読

抄録

Tabanid flies (Tabanidae: Diptera) are common hematophagous insects known to transmit some pathogens mechanically or biologically to animals; they are widely distributed throughout the world. However, no tabanid-borne viruses, except mechanically transmitted viruses, have been reported to date. In this study, we conducted RNA virome analysis of several human-biting tabanid species in Japan, to discover and characterize viruses associated with tabanids. A novel flavivirus was encountered during the study in the Japanese horse fly, Tabanus rufidens (Bigot, 1887). The virus was detected only in T. rufidens, but not in other tabanid species, and as such was designated Tabanus rufidens flavivirus (TrFV). TrFV could not be isolated using a mammalian cell line and showed a closer phylogenetic relationship to the classical insect-specific flaviviruses (cISFs) rather than the vertebrate-infecting flaviviruses (VIFs), suggesting that it is a novel member of the cISFs. The first discovery of a cISF from Brachycera provides new insight into the evolutionary history and dynamics of flaviviruses.

本文言語英語
ページ(範囲)880-890
ページ数11
ジャーナルJournal of Medical Entomology
58
2
DOI
出版ステータス出版済み - 3 1 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 寄生虫科
  • 獣医学(全般)
  • 昆虫科学
  • 感染症

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