Discovery of natural products possessing selective eukaryotic readthrough activity: 3-epi-deoxynegamycin and its leucine adduct

Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Masataka Shiozuka, Hidemasa Nakaminami, Thanigaimalai Pillaiyar, Kentaro Takayama, Fumika Yakushiji, Norihisa Noguchi, Takeo Usui, Ryoichi Matsuda, Yoshio Hayashi

研究成果: Contribution to journalArticle

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Herein we report the first discovery of natural readthrough products that do not display antimicrobial activity. Two natural negamycins, 3-epi-deoxynegamycin and its leucine adduct, isolated 37 years ago, were found to be potent readthrough agents against nonsense mutations of eukaryotes, but not prokaryotes, without displaying antimicrobial activity. These results suggest that the compounds are valuable leads for the development of readthrough drugs against nonsense-mediated genetic diseases without the potential for contributing to the emergence of drug-resistant bacteria.

元の言語英語
ページ(範囲)2233-2237
ページ数5
ジャーナルChemMedChem
9
発行部数10
DOI
出版物ステータス出版済み - 10 1 2014
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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    Taguchi, A., Hamada, K., Kotake, M., Shiozuka, M., Nakaminami, H., Pillaiyar, T., Takayama, K., Yakushiji, F., Noguchi, N., Usui, T., Matsuda, R., & Hayashi, Y. (2014). Discovery of natural products possessing selective eukaryotic readthrough activity: 3-epi-deoxynegamycin and its leucine adduct. ChemMedChem, 9(10), 2233-2237. https://doi.org/10.1002/cmdc.201402208