Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Takahiro Masuya, Masaki Iwamoto, Xiaohui Liu, Ayami Matsushima

研究成果: ジャーナルへの寄稿記事

抄録

Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chemical. BPA interacts not only with oestrogen receptors (ERs) but constitutive androstane receptor, pregnane X receptor, and oestrogen-related receptor γ (ERRγ); therefore, the bisphenol structure represents a privileged structure for the nuclear-receptor superfamily. Here, we screen 127 BPA-related compounds by competitive-binding assay using [3H]oestradiol and find that 20 compounds bind to ERα with high affinity. We confirm most of these as ERα agonists; however, four compounds, including bisphenol M and bisphenol P act as novel antagonists. These structures harbour three benzene rings in tandem with terminal hydroxy groups at para-positions, with this tandem tri-ring bisphenol structure representing a novel privileged structure for an ERα antagonist. Additionally, we perform an ab initio calculation and develop a new clipping method for halogen bonding or non-covalent interaction using DV-Xα evaluation for biomolecules.

元の言語英語
記事番号9954
ジャーナルScientific reports
9
発行部数1
DOI
出版物ステータス出版済み - 12 1 2019

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Cytoplasmic and Nuclear Receptors
Estrogens
Estrogen Receptors
Epoxy Resins
Endocrine Disruptors
Halogens
Competitive Binding
Benzene
Estradiol
bisphenol A
Estrogen Receptor Antagonists

All Science Journal Classification (ASJC) codes

  • General

これを引用

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors. / Masuya, Takahiro; Iwamoto, Masaki; Liu, Xiaohui; Matsushima, Ayami.

:: Scientific reports, 巻 9, 番号 1, 9954, 01.12.2019.

研究成果: ジャーナルへの寄稿記事

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