TY - JOUR
T1 - Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE)
AU - Sawa, Masaaki
AU - Kurokawa, Kiriko
AU - Inoue, Yoshimasa
AU - Kondo, Hirosato
AU - Yoshino, Kohichiro
PY - 2003/6/16
Y1 - 2003/6/16
N2 - A novel series of phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered by structural modification of tetrahydroisoquinoline derivative 1b, which was extremely weak inhibitor of TACE. (S)-Isomer at the phosphorus atom (7b) displayed potent inhibition for TACE, while selectivity sparing MMP-1, -3, and -9.
AB - A novel series of phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered by structural modification of tetrahydroisoquinoline derivative 1b, which was extremely weak inhibitor of TACE. (S)-Isomer at the phosphorus atom (7b) displayed potent inhibition for TACE, while selectivity sparing MMP-1, -3, and -9.
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U2 - 10.1016/S0960-894X(03)00292-0
DO - 10.1016/S0960-894X(03)00292-0
M3 - Article
C2 - 12781187
AN - SCOPUS:0038440615
VL - 13
SP - 2021
EP - 2024
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 12
ER -