Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Masaaki Sawa, Kiriko Kurokawa, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

A novel series of phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered by structural modification of tetrahydroisoquinoline derivative 1b, which was extremely weak inhibitor of TACE. (S)-Isomer at the phosphorus atom (7b) displayed potent inhibition for TACE, while selectivity sparing MMP-1, -3, and -9.

本文言語英語
ページ(範囲)2021-2024
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
13
12
DOI
出版ステータス出版済み - 6 16 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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