Disruption of central antioxidant property of nuclear factor erythroid 2-related factor 2 worsens circulatory homeostasis with baroreflex dysfunction in heart failure

Takuya Kishi

    研究成果: Contribution to journalArticle査読

    1 被引用数 (Scopus)

    抄録

    Heart failure is defined as a disruption of circulatory homeostasis. We have demonstrated that baroreflex dysfunction strikingly disrupts circulatory homeostasis. Moreover, previous many reports have suggested that central excess oxidative stress causes sympathoexcitation in heart failure. However, the central mechanisms of baroreflex dysfunction with oxidative stress has not been fully clarified. Our hypothesis was that the impairment of central antioxidant property would worsen circulatory homeostasis with baroreflex dysfunction in heart failure. As the major antioxidant property in the brain, we focused on nuclear factor erythroid 2-related factor 2 (Nrf2; cytoprotective transcription factor). Hemodynamic and baroreflex function in conscious state were assessed by the radio-telemetry system. In the heart failure treated with intracerebroventricular (ICV) infusion of angiotensin II type 1 receptor blocker (ARB), sympathetic activation and brain oxidative stress were significantly lower, and baroreflex sensitivity and volume tolerance were significantly higher than in heart failure treated with vehicle. ICV infusion of Nrf2 activator decreased sympathetic activation and brain oxidative stress, and increased baroreflex sensitivity and volume tolerance to a greater extent than ARB. In conclusion, the disruption of central antioxidant property of Nrf2 worsened circulatory homeostasis with baroreflex dysfunction in heart failure.

    本文言語英語
    論文番号646
    ジャーナルInternational journal of molecular sciences
    19
    3
    DOI
    出版ステータス出版済み - 3 2018

    All Science Journal Classification (ASJC) codes

    • 触媒
    • 分子生物学
    • 分光学
    • コンピュータ サイエンスの応用
    • 物理化学および理論化学
    • 有機化学
    • 無機化学

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