Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans

Mark I.R. Petalcorin, Toshihiko Oka, Makoto Koga, Ken Ichi Ogura, Yoh Wada, Yasumi Ohshima, Masamitsu Futai

研究成果: Contribution to journalArticle査読

23 被引用数 (Scopus)

抄録

We cloned the clh-1 gene coding for a putative ClC chloride channel in Caenorhabditis elegans. The gene product exhibited a high degree of homology with human ClC-1 and ClC-2. The clh-1 gene was predominantly expressed in the hypodermis, including seam cells. Null mutations of clh-1 caused a significantly wider body and an abnormal alae structure. High osmolarity in the culture medium restored the normal body width of the clh-1 mutants. These results suggest that the clh-1 gene contributes to maintenance of the body width through regulation of osmolarity.

本文言語英語
ページ(範囲)347-355
ページ数9
ジャーナルJournal of Molecular Biology
294
2
DOI
出版ステータス出版済み - 11 26 1999

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 分子生物学

フィンガープリント

「Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル