Disruption of the hslU gene, which encodes an ATPase subunit of the eukaryotic 26S proteasome homolog in Escherichia coli, suppresses the temperature-sensitive dnaA46 mutation

Tsutomu Katayama, Toshio Kubota, Makoto Takata, Nobuyoshi Akimitsu, Kazuhisa Sekimizu

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

The Escherichia coil hslVU genes encode subunits of an ATP-dependent protease, a homolog of the eukaryotic 265 proteasome. We found that the hslU gene is required for the temperature (40°C)-sensitive phenotype of the dnaA46 mutant, while other soluble ATP-dependent proteases, La (Lon) and Ti (Clp), were unrelated to this dnaA46 phenotype. Disruption of the hslU gene inhibited cell growth at high temperatures. These observations suggest a specific in vivo role for HslVU protease in denatured proteins. As the absence of HslU produces minicells in M9 medium, the protease may be involved in the cell cycle regulation.

本文言語英語
ページ(範囲)219-224
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
229
1
DOI
出版ステータス出版済み - 12 4 1996

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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