Disseminated bacillus calmette-guérin lymphadenitis in a patient with gp91phox - Chronic granulomatous disease 25 years after vaccination

Koichi Kusuhara, Shouichi Ohga, Takayuki Hoshina, Mitsumasa Saito, Yuka Sasaki, Masataka Ishimura, Hidetoshi Takada, Masaki Fujita, Toshiro Hara

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

A boy developed ipsilateral axillary lymphadenitis after Bacillus Calmette-Guérin (BCG) inoculation at the age of 5 months. Subsequently, he was diagnosed with X-linked chronic granulomatous disease (CGD) by the nitroblue tetrazolium assay when he was 4 years old. Body computerized tomography (CT) performed at the age of 25 years showed enlarged lymph nodes in the left periclavicular and axillary regions, and was confirmed by gallium scintigraphy. Mycobacterial culture, smear, and polymerase chain reaction (PCR) of the sputum and gastric fluid were negative. Whole-blood IFN-γ assay was negative as well. Mycobacterium bovis BCG was isolated from the lymph node biopsy by PCR amplification and culture. No mutation of the IFN-γ receptor 1 could be identified. In conclusion, CGD can be the underlying condition for BCG-itis; whole-blood IFN-γ assay might be useful in differentiating BCG infection and tuberculosis in CGD patients; BCG vaccination is contraindicated in X-linked CGD.

本文言語英語
ページ(範囲)745-747
ページ数3
ジャーナルEuropean Journal of Pediatrics
168
6
DOI
出版ステータス出版済み - 6 2009

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康

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