Disseminated tuberculosis following second unrelated cord blood transplantation for acute myelogenous leukemia

T. Shima, G. Yoshimoto, T. Miyamoto, S. Yoshida, K. Kamezaki, K. Takenaka, H. Iwasaki, N. Harada, K. Nagafuji, T. Teshima, N. Shimono, K. Akashi

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Here we report the case of a 43-year-old Japanese woman with acute myelogenous leukemia who underwent 2 unrelated cord blood transplantations (UCBT), terminating in fatal disseminated tuberculosis (TB). The patient did not achieve remission despite intensive chemotherapy, and subsequently underwent UCBT with a standard conditioning regimen. However, engraftment was not achieved. Fifty days after the first UCBT, the patient underwent a second UCBT with a reduced-intensity conditioning regimen. She developed a pre-engraftment immune reaction, which responded well to prednisolone, and engraftment was documented. However, 50 days after the second UCBT, the patient presented with high fever and developed pneumonia despite antibiotic and antifungal treatments. Thereafter, Mycobacterium tuberculosis was detected in blood cultures and specimens of bronchoalveolar lavage, thus indicating disseminated TB. Despite anti-tuberculous treatment, she died on day 85. TB should always be considered as a possible diagnosis when treating febrile immunocompromised patients.

本文言語英語
ページ(範囲)75-77
ページ数3
ジャーナルTransplant Infectious Disease
11
1
DOI
出版ステータス出版済み - 2 1 2009

All Science Journal Classification (ASJC) codes

  • 感染症
  • 移植

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