Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis

M. Tanaka, Takuya Matsushita, T. Tateishi, H. Ochi, Y. Kawano, F. J. Mei, M. Minohara, Hiroyuki Murai, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

64 引用 (Scopus)

抄録

BACKGROUND: We reported the emergence of a distinct myelitis in patients with atopic diathesis (atopic myelitis [AM]) by a nationwide survey throughout Japan. Similar cases have recently been reported in Caucasians. Pathologic studies of biopsied spinal cord specimens revealed chronic active inflammation with eosinophilic infiltration. OBJECTIVE: To clarify the cytokine/chemokine alterations in CSF from patients with AM in comparison to other causes of myelitis. METHODS: We measured 27 cytokines, chemokines, and growth factors simultaneously in CSF from 22 patients with AM, 20 with opticospinal multiple sclerosis (OSMS), 11 with HTLV-1-associated myelopathy (HAM), 9 with Sjögren syndrome-related myelitis (SM), and 20 with other noninflammatory neurologic diseases (OND), using a fluorescent bead-based immunoassay. RESULTS: In patients with AM, CCL11 and interleukin (IL)-9 were significantly increased as compared with patients with OND and other myelitis while in patients with OSMS interferon-γ and granulocyte-colony stimulating factor levels were significantly higher than in patients with OND and other causes of myelitis. Significant increase of IL-17 in comparison to patients with OND was found only in patients with OSMS, irrespective of presence or absence of anti-aquaporin-4 (AQP4) antibody. In patients with HAM, CXCL10 and CCL5 were higher than in patients with OND and other myelitis. In patients with SM, CCL3 and CCL4 were higher than in patients with OND. In patients with AM, CCL11, IL-9, and IL-1 receptor antagonist (IL-1ra) showed positive correlations with the final Kurtzke Expanded Disability Status Scale scores while IL-1ra and IL-12(p70) had positive correlations with disease duration. CONCLUSION: Intrathecal upregulation of CCL11 and Th2 cytokines is characteristic of atopic myelitis, which is distinct from interleukin-17/ interferon-γ-related autoimmune condition of opticospinal multiple sclerosis.

元の言語英語
ページ(範囲)974-981
ページ数8
ジャーナルNeurology
71
発行部数13
DOI
出版物ステータス出版済み - 9 23 2008

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Myelitis
Chemokines
Cytokines
Nervous System Diseases
Interleukin-9
Human T-lymphotropic virus 1
Interleukin-17
Spinal Cord Diseases
Interferons
Aquaporin 4
Interleukin-1 Receptors
Interleukins
Disease Susceptibility
Granulocyte Colony-Stimulating Factor
Interleukin-12
Immunoassay

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

これを引用

Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis. / Tanaka, M.; Matsushita, Takuya; Tateishi, T.; Ochi, H.; Kawano, Y.; Mei, F. J.; Minohara, M.; Murai, Hiroyuki; Kira, Jun-Ichi.

:: Neurology, 巻 71, 番号 13, 23.09.2008, p. 974-981.

研究成果: ジャーナルへの寄稿記事

Tanaka, M, Matsushita, T, Tateishi, T, Ochi, H, Kawano, Y, Mei, FJ, Minohara, M, Murai, H & Kira, J-I 2008, 'Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis', Neurology, 巻. 71, 番号 13, pp. 974-981. https://doi.org/10.1212/01.wnl.0000326589.57128.c3
Tanaka, M. ; Matsushita, Takuya ; Tateishi, T. ; Ochi, H. ; Kawano, Y. ; Mei, F. J. ; Minohara, M. ; Murai, Hiroyuki ; Kira, Jun-Ichi. / Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis. :: Neurology. 2008 ; 巻 71, 番号 13. pp. 974-981.
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title = "Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis",
abstract = "BACKGROUND: We reported the emergence of a distinct myelitis in patients with atopic diathesis (atopic myelitis [AM]) by a nationwide survey throughout Japan. Similar cases have recently been reported in Caucasians. Pathologic studies of biopsied spinal cord specimens revealed chronic active inflammation with eosinophilic infiltration. OBJECTIVE: To clarify the cytokine/chemokine alterations in CSF from patients with AM in comparison to other causes of myelitis. METHODS: We measured 27 cytokines, chemokines, and growth factors simultaneously in CSF from 22 patients with AM, 20 with opticospinal multiple sclerosis (OSMS), 11 with HTLV-1-associated myelopathy (HAM), 9 with Sj{\"o}gren syndrome-related myelitis (SM), and 20 with other noninflammatory neurologic diseases (OND), using a fluorescent bead-based immunoassay. RESULTS: In patients with AM, CCL11 and interleukin (IL)-9 were significantly increased as compared with patients with OND and other myelitis while in patients with OSMS interferon-γ and granulocyte-colony stimulating factor levels were significantly higher than in patients with OND and other causes of myelitis. Significant increase of IL-17 in comparison to patients with OND was found only in patients with OSMS, irrespective of presence or absence of anti-aquaporin-4 (AQP4) antibody. In patients with HAM, CXCL10 and CCL5 were higher than in patients with OND and other myelitis. In patients with SM, CCL3 and CCL4 were higher than in patients with OND. In patients with AM, CCL11, IL-9, and IL-1 receptor antagonist (IL-1ra) showed positive correlations with the final Kurtzke Expanded Disability Status Scale scores while IL-1ra and IL-12(p70) had positive correlations with disease duration. CONCLUSION: Intrathecal upregulation of CCL11 and Th2 cytokines is characteristic of atopic myelitis, which is distinct from interleukin-17/ interferon-γ-related autoimmune condition of opticospinal multiple sclerosis.",
author = "M. Tanaka and Takuya Matsushita and T. Tateishi and H. Ochi and Y. Kawano and Mei, {F. J.} and M. Minohara and Hiroyuki Murai and Jun-Ichi Kira",
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T1 - Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis

AU - Tanaka, M.

AU - Matsushita, Takuya

AU - Tateishi, T.

AU - Ochi, H.

AU - Kawano, Y.

AU - Mei, F. J.

AU - Minohara, M.

AU - Murai, Hiroyuki

AU - Kira, Jun-Ichi

PY - 2008/9/23

Y1 - 2008/9/23

N2 - BACKGROUND: We reported the emergence of a distinct myelitis in patients with atopic diathesis (atopic myelitis [AM]) by a nationwide survey throughout Japan. Similar cases have recently been reported in Caucasians. Pathologic studies of biopsied spinal cord specimens revealed chronic active inflammation with eosinophilic infiltration. OBJECTIVE: To clarify the cytokine/chemokine alterations in CSF from patients with AM in comparison to other causes of myelitis. METHODS: We measured 27 cytokines, chemokines, and growth factors simultaneously in CSF from 22 patients with AM, 20 with opticospinal multiple sclerosis (OSMS), 11 with HTLV-1-associated myelopathy (HAM), 9 with Sjögren syndrome-related myelitis (SM), and 20 with other noninflammatory neurologic diseases (OND), using a fluorescent bead-based immunoassay. RESULTS: In patients with AM, CCL11 and interleukin (IL)-9 were significantly increased as compared with patients with OND and other myelitis while in patients with OSMS interferon-γ and granulocyte-colony stimulating factor levels were significantly higher than in patients with OND and other causes of myelitis. Significant increase of IL-17 in comparison to patients with OND was found only in patients with OSMS, irrespective of presence or absence of anti-aquaporin-4 (AQP4) antibody. In patients with HAM, CXCL10 and CCL5 were higher than in patients with OND and other myelitis. In patients with SM, CCL3 and CCL4 were higher than in patients with OND. In patients with AM, CCL11, IL-9, and IL-1 receptor antagonist (IL-1ra) showed positive correlations with the final Kurtzke Expanded Disability Status Scale scores while IL-1ra and IL-12(p70) had positive correlations with disease duration. CONCLUSION: Intrathecal upregulation of CCL11 and Th2 cytokines is characteristic of atopic myelitis, which is distinct from interleukin-17/ interferon-γ-related autoimmune condition of opticospinal multiple sclerosis.

AB - BACKGROUND: We reported the emergence of a distinct myelitis in patients with atopic diathesis (atopic myelitis [AM]) by a nationwide survey throughout Japan. Similar cases have recently been reported in Caucasians. Pathologic studies of biopsied spinal cord specimens revealed chronic active inflammation with eosinophilic infiltration. OBJECTIVE: To clarify the cytokine/chemokine alterations in CSF from patients with AM in comparison to other causes of myelitis. METHODS: We measured 27 cytokines, chemokines, and growth factors simultaneously in CSF from 22 patients with AM, 20 with opticospinal multiple sclerosis (OSMS), 11 with HTLV-1-associated myelopathy (HAM), 9 with Sjögren syndrome-related myelitis (SM), and 20 with other noninflammatory neurologic diseases (OND), using a fluorescent bead-based immunoassay. RESULTS: In patients with AM, CCL11 and interleukin (IL)-9 were significantly increased as compared with patients with OND and other myelitis while in patients with OSMS interferon-γ and granulocyte-colony stimulating factor levels were significantly higher than in patients with OND and other causes of myelitis. Significant increase of IL-17 in comparison to patients with OND was found only in patients with OSMS, irrespective of presence or absence of anti-aquaporin-4 (AQP4) antibody. In patients with HAM, CXCL10 and CCL5 were higher than in patients with OND and other myelitis. In patients with SM, CCL3 and CCL4 were higher than in patients with OND. In patients with AM, CCL11, IL-9, and IL-1 receptor antagonist (IL-1ra) showed positive correlations with the final Kurtzke Expanded Disability Status Scale scores while IL-1ra and IL-12(p70) had positive correlations with disease duration. CONCLUSION: Intrathecal upregulation of CCL11 and Th2 cytokines is characteristic of atopic myelitis, which is distinct from interleukin-17/ interferon-γ-related autoimmune condition of opticospinal multiple sclerosis.

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