Distinct profiles of soluble cytokine receptors between b-cell vitreoretinal lymphoma and uveitis

Atsunobu Takeda, Hiroshi Yoshikawa, Takako Fukuhara, Shin Ichi Hikita, Kuniaki Hijioka, Takaaki Otomo, Ryoichi Arita, Toshio Hisatomi, Kazuhiro Kimura, Shigeo Yoshida, Yo Ichi Kawano, Koh Hei Sonoda, Tatsuro Ishibashi

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

PURPOSE. To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS. Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathic epiretinal membrane (n = 21) as controls. Cytometric beads assay were used to determine the vitreous concentrations of soluble receptors and cytokines. RESULTS. Vitreous levels of soluble IL-2 receptor α (sIL-2Ra), sIL-6R, soluble tumor necrosis factor receptor (TNFR) 1, sTNFR2, soluble vascular endothelial growth factor receptor (sVEGFR) 1, sVEGFR2, and IL-10 were higher in patients with VRL than in those with uveitis and controls, whereas those of sIL-1R1, sIL-1R2, and sIL-4R were higher in patients with uveitis than those with VRL and controls. In analyses in patients with VRL, elevation of sVEGFR1 and sVEGFR2 levels was more prominent in patients with systemic metastatic retinal lymphoma (SMRL) than in those with primary VRL/primary central nervous system lymphoma (PVRL/PCNSL). Furthermore, sIL-2Rα levels were increased in patients with VRL who developed subretinal lesions compared with in those who mainly had vitreous cavity opacity, positively correlated with the density of CD3+ cells in the vitrectomy cell blocks. CONCLUSIONS. The profiles of soluble cytokine receptors and cytokines in patients with VRL were different from those with uveitis. In addition, sVEGFR1 and sVEGFR2 levels may be differential diagnostic markers between PVRL/PCNSL and SMRL, and sIL-2Rα levels can anticipate infiltration of VRL cells into the subretina and/or retina.

元の言語英語
ページ(範囲)7516-7523
ページ数8
ジャーナルInvestigative Ophthalmology and Visual Science
56
発行部数12
DOI
出版物ステータス出版済み - 1 1 2015

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Cytokine Receptors
Uveitis
Lymphoma
Central Nervous System
Cytokines
Epiretinal Membrane
Vascular Endothelial Growth Factor Receptor-1
Vitreous Body
Tumor Necrosis Factor Receptors
Interleukin-2 Receptors
Vitrectomy
B-Cell Lymphoma
Interleukin-10
Retina
Cell Count

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

これを引用

Distinct profiles of soluble cytokine receptors between b-cell vitreoretinal lymphoma and uveitis. / Takeda, Atsunobu; Yoshikawa, Hiroshi; Fukuhara, Takako; Hikita, Shin Ichi; Hijioka, Kuniaki; Otomo, Takaaki; Arita, Ryoichi; Hisatomi, Toshio; Kimura, Kazuhiro; Yoshida, Shigeo; Kawano, Yo Ichi; Sonoda, Koh Hei; Ishibashi, Tatsuro.

:: Investigative Ophthalmology and Visual Science, 巻 56, 番号 12, 01.01.2015, p. 7516-7523.

研究成果: ジャーナルへの寄稿記事

Takeda, A, Yoshikawa, H, Fukuhara, T, Hikita, SI, Hijioka, K, Otomo, T, Arita, R, Hisatomi, T, Kimura, K, Yoshida, S, Kawano, YI, Sonoda, KH & Ishibashi, T 2015, 'Distinct profiles of soluble cytokine receptors between b-cell vitreoretinal lymphoma and uveitis', Investigative Ophthalmology and Visual Science, 巻. 56, 番号 12, pp. 7516-7523. https://doi.org/10.1167/iovs.15-17465
Takeda, Atsunobu ; Yoshikawa, Hiroshi ; Fukuhara, Takako ; Hikita, Shin Ichi ; Hijioka, Kuniaki ; Otomo, Takaaki ; Arita, Ryoichi ; Hisatomi, Toshio ; Kimura, Kazuhiro ; Yoshida, Shigeo ; Kawano, Yo Ichi ; Sonoda, Koh Hei ; Ishibashi, Tatsuro. / Distinct profiles of soluble cytokine receptors between b-cell vitreoretinal lymphoma and uveitis. :: Investigative Ophthalmology and Visual Science. 2015 ; 巻 56, 番号 12. pp. 7516-7523.
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abstract = "PURPOSE. To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS. Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathic epiretinal membrane (n = 21) as controls. Cytometric beads assay were used to determine the vitreous concentrations of soluble receptors and cytokines. RESULTS. Vitreous levels of soluble IL-2 receptor α (sIL-2Ra), sIL-6R, soluble tumor necrosis factor receptor (TNFR) 1, sTNFR2, soluble vascular endothelial growth factor receptor (sVEGFR) 1, sVEGFR2, and IL-10 were higher in patients with VRL than in those with uveitis and controls, whereas those of sIL-1R1, sIL-1R2, and sIL-4R were higher in patients with uveitis than those with VRL and controls. In analyses in patients with VRL, elevation of sVEGFR1 and sVEGFR2 levels was more prominent in patients with systemic metastatic retinal lymphoma (SMRL) than in those with primary VRL/primary central nervous system lymphoma (PVRL/PCNSL). Furthermore, sIL-2Rα levels were increased in patients with VRL who developed subretinal lesions compared with in those who mainly had vitreous cavity opacity, positively correlated with the density of CD3+ cells in the vitrectomy cell blocks. CONCLUSIONS. The profiles of soluble cytokine receptors and cytokines in patients with VRL were different from those with uveitis. In addition, sVEGFR1 and sVEGFR2 levels may be differential diagnostic markers between PVRL/PCNSL and SMRL, and sIL-2Rα levels can anticipate infiltration of VRL cells into the subretina and/or retina.",
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T1 - Distinct profiles of soluble cytokine receptors between b-cell vitreoretinal lymphoma and uveitis

AU - Takeda, Atsunobu

AU - Yoshikawa, Hiroshi

AU - Fukuhara, Takako

AU - Hikita, Shin Ichi

AU - Hijioka, Kuniaki

AU - Otomo, Takaaki

AU - Arita, Ryoichi

AU - Hisatomi, Toshio

AU - Kimura, Kazuhiro

AU - Yoshida, Shigeo

AU - Kawano, Yo Ichi

AU - Sonoda, Koh Hei

AU - Ishibashi, Tatsuro

PY - 2015/1/1

Y1 - 2015/1/1

N2 - PURPOSE. To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS. Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathic epiretinal membrane (n = 21) as controls. Cytometric beads assay were used to determine the vitreous concentrations of soluble receptors and cytokines. RESULTS. Vitreous levels of soluble IL-2 receptor α (sIL-2Ra), sIL-6R, soluble tumor necrosis factor receptor (TNFR) 1, sTNFR2, soluble vascular endothelial growth factor receptor (sVEGFR) 1, sVEGFR2, and IL-10 were higher in patients with VRL than in those with uveitis and controls, whereas those of sIL-1R1, sIL-1R2, and sIL-4R were higher in patients with uveitis than those with VRL and controls. In analyses in patients with VRL, elevation of sVEGFR1 and sVEGFR2 levels was more prominent in patients with systemic metastatic retinal lymphoma (SMRL) than in those with primary VRL/primary central nervous system lymphoma (PVRL/PCNSL). Furthermore, sIL-2Rα levels were increased in patients with VRL who developed subretinal lesions compared with in those who mainly had vitreous cavity opacity, positively correlated with the density of CD3+ cells in the vitrectomy cell blocks. CONCLUSIONS. The profiles of soluble cytokine receptors and cytokines in patients with VRL were different from those with uveitis. In addition, sVEGFR1 and sVEGFR2 levels may be differential diagnostic markers between PVRL/PCNSL and SMRL, and sIL-2Rα levels can anticipate infiltration of VRL cells into the subretina and/or retina.

AB - PURPOSE. To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS. Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathic epiretinal membrane (n = 21) as controls. Cytometric beads assay were used to determine the vitreous concentrations of soluble receptors and cytokines. RESULTS. Vitreous levels of soluble IL-2 receptor α (sIL-2Ra), sIL-6R, soluble tumor necrosis factor receptor (TNFR) 1, sTNFR2, soluble vascular endothelial growth factor receptor (sVEGFR) 1, sVEGFR2, and IL-10 were higher in patients with VRL than in those with uveitis and controls, whereas those of sIL-1R1, sIL-1R2, and sIL-4R were higher in patients with uveitis than those with VRL and controls. In analyses in patients with VRL, elevation of sVEGFR1 and sVEGFR2 levels was more prominent in patients with systemic metastatic retinal lymphoma (SMRL) than in those with primary VRL/primary central nervous system lymphoma (PVRL/PCNSL). Furthermore, sIL-2Rα levels were increased in patients with VRL who developed subretinal lesions compared with in those who mainly had vitreous cavity opacity, positively correlated with the density of CD3+ cells in the vitrectomy cell blocks. CONCLUSIONS. The profiles of soluble cytokine receptors and cytokines in patients with VRL were different from those with uveitis. In addition, sVEGFR1 and sVEGFR2 levels may be differential diagnostic markers between PVRL/PCNSL and SMRL, and sIL-2Rα levels can anticipate infiltration of VRL cells into the subretina and/or retina.

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