Distribution of basement membrane antigens in human esophageal lesions: An immunohistochemical study

Masaki Mori, Reishi Shimono, Akinori Kido, Hiroyuki Kuwano, Kouhei Akazawa, Keizo Sugimachi

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)

抄録

The distribution of basement membrane components, type‐IV collagen and laminin, was studied immunohistochemically in human samples of normal, hyperplastic, dysplastic and carcinomatous esophageal tissue. The expression of basement membrane components in normal, hyperplastic, and mildly and moderately dysplastic mucosa was characterized by a thick, continuous and linear staining pattern. In severe dysplasia and carcinoma in situ, the basement membrane was thinner and occasionally discontinuous. The distribution of basement membrane in invasive carcinomas varied greatly; well‐differentiated, cohesive tumors had a basement membrane, however, poorly‐differentiated tumors showing irregular cords, or individual cell infiltration, lacked this membrane at the tumor‐stromal interface. Many moderately‐differentiated tumors showed probable immature assembly of basement membrane components. The expression of basement membrane was also influenced by the extent of stromal inflammation. The absence or presence (staining pattern) of basement membrane components in esophageal squamous‐cell carcinoma did not correlate with the survival rate, but did correlate with the histologic differentiation of epithelial organization.

本文言語英語
ページ(範囲)839-842
ページ数4
ジャーナルInternational Journal of Cancer
47
6
DOI
出版ステータス出版済み - 4月 1 1991

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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