Distribution of basement membrane antigens in the uterine cervical adenocarcinomas: An immunohistochemical study

Naoyuki Toki, Tsunehisa Kaku, Naoki Tsukamoto, Mariko Matsumura, Toshiaki Saito, Toshiharu Kamura, Toshitaka Matsuyama, Hitoo Nakano

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

The distribution of laminin and collagen type IV in the basement membrane of 45 uterine cervical adenocarcinomas was studied using immunohistochemical techniques. Staining patterns of basement membranes were divided into three types, according to the intensity of staining: thick and discontinuous (type I), thin and discontinuous (type II), and fragmentary (type III). In well-differentiated adenocarcinomas, 17 of 24 cases (71%) showed type I and the remaining 7 showed type II. In contrast, in poorly differentiated adenocarcinomas 4 of 5 cases (80%) showed type III. Five of six cases (83%) of adenoma malignum, even though extremely well differentiated, showed type III. Staining patterns of the basement membranes correlated with histological grade. Five-year survival rate of patients with type I and II staining (74%) was better than that of patients with type III (55%).

本文言語英語
ページ(範囲)17-21
ページ数5
ジャーナルGynecologic Oncology
38
1
DOI
出版ステータス出版済み - 7月 1990

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 産婦人科学

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