TY - JOUR
T1 - Distribution of basement membrane antigens in the uterine cervical adenocarcinomas
T2 - An immunohistochemical study
AU - Toki, Naoyuki
AU - Kaku, Tsunehisa
AU - Tsukamoto, Naoki
AU - Matsumura, Mariko
AU - Saito, Toshiaki
AU - Kamura, Toshiharu
AU - Matsuyama, Toshitaka
AU - Nakano, Hitoo
N1 - Funding Information:
This study was supported by Grant-in-Aid for Scientific Research 6357112f5r om the Ministry of Education, Science and Culture of Japan. This study was presented in part at the 41st Annual Meeting of the Japan Society of Obstetricsa nd Gynecology, Okayama,J apan, in April 1989.W e are very grateful to Mrs. Kazuko Koto for her skillful technical assistance.
PY - 1990/7
Y1 - 1990/7
N2 - The distribution of laminin and collagen type IV in the basement membrane of 45 uterine cervical adenocarcinomas was studied using immunohistochemical techniques. Staining patterns of basement membranes were divided into three types, according to the intensity of staining: thick and discontinuous (type I), thin and discontinuous (type II), and fragmentary (type III). In well-differentiated adenocarcinomas, 17 of 24 cases (71%) showed type I and the remaining 7 showed type II. In contrast, in poorly differentiated adenocarcinomas 4 of 5 cases (80%) showed type III. Five of six cases (83%) of adenoma malignum, even though extremely well differentiated, showed type III. Staining patterns of the basement membranes correlated with histological grade. Five-year survival rate of patients with type I and II staining (74%) was better than that of patients with type III (55%).
AB - The distribution of laminin and collagen type IV in the basement membrane of 45 uterine cervical adenocarcinomas was studied using immunohistochemical techniques. Staining patterns of basement membranes were divided into three types, according to the intensity of staining: thick and discontinuous (type I), thin and discontinuous (type II), and fragmentary (type III). In well-differentiated adenocarcinomas, 17 of 24 cases (71%) showed type I and the remaining 7 showed type II. In contrast, in poorly differentiated adenocarcinomas 4 of 5 cases (80%) showed type III. Five of six cases (83%) of adenoma malignum, even though extremely well differentiated, showed type III. Staining patterns of the basement membranes correlated with histological grade. Five-year survival rate of patients with type I and II staining (74%) was better than that of patients with type III (55%).
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U2 - 10.1016/0090-8258(90)90004-5
DO - 10.1016/0090-8258(90)90004-5
M3 - Article
C2 - 2354821
AN - SCOPUS:0025312775
VL - 38
SP - 17
EP - 21
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 1
ER -