Distribution of nanoparticle depositions after a single breathing in a murine pulmonary acinus model

Toshihiro Sera, Ryosuke Higashi, Hisashi Naito, Takeshi Matsumoto, Masao Tanaka

    研究成果: Contribution to journalArticle査読

    6 被引用数 (Scopus)


    We quantitatively investigated nanoparticle deposition (density: 1.0 g/cm3, diameter: 0.1–1.0 μm) in a pulmonary acinus using computational fluid dynamics. We assumed that acinar flow was induced by the expansion and contraction of the acinar model, with the volume changing sinusoidally with time as the boundary condition. We based the complicated acinar model and volume change on a mammalian lung, and evaluated the distribution of particle depositions through acinar generation based on three dimensional thinning. The maximum Reynolds numbers at the inlet and terminal alveoli were 0.191 and 1.93 × 10−3, respectively. With only gravitational force, particle deposition was strongly affected, except for the 0.1- and 0.2-μm particles, and the 0.8- and 1.0-μm particles were deposited around the inlet due to sedimentation after the beginning of inflation. We found that the 0.1- to 0.4-μm particles were deposited at the distal alveoli and that the deposition was enhanced by both the gravitational and Brownian forces, despite the small terminal velocity. For the 0.1- and 0.2-μm particles in particular, the particles were deposited throughout the acinus. The maximum deposition fraction of each acinar segment reached 1.2% after a single breath, and was higher in the middle generations and at the terminal alveoli.

    ジャーナルInternational Journal of Heat and Mass Transfer
    出版ステータス出版済み - 2017

    All Science Journal Classification (ASJC) codes

    • 凝縮系物理学
    • 機械工学
    • 流体および伝熱


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