Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y 6 receptor system

Fumiko Takayama, Yoshinori Hayashi, Zhou Wu, Yicong Liu, Hiroshi Nakanishi

研究成果: Contribution to journalArticle査読

28 被引用数 (Scopus)

抄録

It has long been believed that microglia morphologically transform into the activated state by retracting their long processes and consuming pathogens when bacteria infect into the brain parenchyma. In the present study, however, we showed for the first time that murine cortical microglia extend their processes towards focally injected Porphyromonas gingivalis. This P. gingivalis-induced microglial process extension was significantly increased during the light (sleeping) phase than the dark (waking) phase. In contrast, focally injected ATP-induced microglial process extension was significantly increased during the dark phase than the light phase. Furthermore, in contrast to the P2Y 12 receptor-mediated mechanism of ATP-induced microglial process extension, the P. gingivalis-mediated microglial process extension was mediated by P2Y 6 receptors. The infection of bacteria such as P. gingivalis to the brain parenchyma may induce the secretion of UDP from microglia at the site of infection, which in turn induces the process extension of the neighboring microglia.

本文言語英語
論文番号30006
ジャーナルScientific reports
6
DOI
出版ステータス出版済み - 7 21 2016

All Science Journal Classification (ASJC) codes

  • 一般

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