Diverse function of epiprofin in tooth development

Takashi Nakamura, Satoshi Fukumoto, Yoshihiko Yamada

研究成果: ジャーナルへの寄稿評論記事

5 引用 (Scopus)

抄録

The developing tooth is a good model for studying the mechanism of organogenesis. Tooth development begins as the placode formation with the thickening and invaginating of the oral ectoderm into the dental mesenchyme. A series of reciprocal interactions between these two cell types give rise to differentiation into various cell types including epithelial-derived enamel-secreting ameloblasts and neural crest-derived dentin-secreting odontoblasts. A number of transcription factors control tooth development in order to form unique structures specialized for tooth function with optimized shapes and sizes. We identified Epi-profin (Epfn) as a transcription factor preferentially expressed in teeth. Epfn KO mice display profound embryonic and postnatal growth retardation and develop impaired hair follicle and whisker formation. The drastic phenotypes of Epfn KO are supernumerary tooth formation and lack of enamel in teeth. These observations suggest that Epiprofin plays critical roles in ectodermal organ development and regulates the number of teeth. This review summarizes the roles of Epiprofin in tooth development.

元の言語英語
ページ(範囲)22-30
ページ数9
ジャーナルjournal of oral biosciences
53
発行部数1
DOI
出版物ステータス出版済み - 2011

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Enamels
Tooth
Transcription Factors
Dental Enamel
Supernumerary Tooth
Ameloblasts
Odontoblasts
Vibrissae
Ectoderm
Organogenesis
Hair Follicle
Neural Crest
Mesoderm
Dentin
Epithelial Cells
Phenotype

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dentistry(all)

これを引用

Diverse function of epiprofin in tooth development. / Nakamura, Takashi; Fukumoto, Satoshi; Yamada, Yoshihiko.

:: journal of oral biosciences, 巻 53, 番号 1, 2011, p. 22-30.

研究成果: ジャーナルへの寄稿評論記事

Nakamura, Takashi ; Fukumoto, Satoshi ; Yamada, Yoshihiko. / Diverse function of epiprofin in tooth development. :: journal of oral biosciences. 2011 ; 巻 53, 番号 1. pp. 22-30.
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