Diverse ubiquitin codes in the regulation of inflammatory signaling

Fumiyo Ikeda, M. J.A. Shigekazu Nagata

研究成果: Contribution to journalReview article査読

抄録

Ubiquitin is a small protein used for posttranslational modification and it regulates every aspect of biological functions. Through a three-step cascade of enzymatic action, ubiquitin is conjugated to a substrate. Because ubiquitin itself can be post-translationally modified, this small protein generates various ubiquitin codes and triggers differing regulation of biological functions. For example, ubiquitin itself can be ubiquitinated, phosphorylated, acetylated, or SUMOylated. Via the type three secretion system, some bacterial effectors also modify the ubiquitin system in host cells. This review describes the general concept of the ubiquitin system as well as the fundamental functions of ubiquitin in the regulation of cellular responses during inflammation and bacterial infection.

本文言語英語
ページ(範囲)431-439
ページ数9
ジャーナルProceedings of the Japan Academy Series B: Physical and Biological Sciences
96
9
DOI
出版ステータス出版済み - 2020

All Science Journal Classification (ASJC) codes

  • 農業および生物科学(全般)
  • 物理学および天文学(全般)

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