Diversity in gut bacterial community of school-age children in Asia

Jiro Nakayama, Koichi Watanabe, Jiahui Jiang, Kazunori Matsuda, Shiou Huei Chao, Pri Haryono, Orawan La-Ongkham, Martinus Agus Sarwoko, I. Nengah Sujaya, Liang Zhao, Kang Ting Chen, Yen Po Chen, Hsueh Hui Chiu, Tomoko Hidaka, Ning Xin Huang, Chikako Kiyohara, Takashi Kurakawa, Naoshige Sakamoto, Kenji Sonomoto, Kosuke Tashiro & 9 others Hirokazu Tsuji, Ming Ju Chen, Vichai Leelavatcharamas, Chii Cherng Liao, Sunee Nitisinprasert, Endang S. Rahayu, Fa Zheng Ren, Ying Chieh Tsai, Yuan Kun Lee

研究成果: ジャーナルへの寄稿記事

94 引用 (Scopus)

抄録

Asia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures and dietary habits. To address the diversity in their gut microbiota, we characterized the bacterial community in fecal samples obtained from 303 school-age children living in urban or rural regions in five countries spanning temperate and tropical areas of Asia. The microbiota profiled for the 303 subjects were classified into two enterotype-like clusters, each driven by Prevotella (P-type) or Bifidobacterium/Bacteroides (BB-type), respectively. Majority in China, Japan and Taiwan harbored BB-type, whereas those from Indonesia and Khon Kaen in Thailand mainly harbored P-type. The P-type microbiota was characterized by a more conserved bacterial community sharing a greater number of type-specific phylotypes. Predictive metagenomics suggests higher and lower activity of carbohydrate digestion and bile acid biosynthesis, respectively, in P-type subjects, reflecting their high intake of diets rich in resistant starch. Random-forest analysis classified their fecal species community as mirroring location of resident country, suggesting eco-geographical factors shaping gut microbiota. In particular, children living in Japan harbored a less diversified microbiota with high abundance of Bifidobacterium and less number of potentially pathogenic bacteria, which may reflect their living environment and unique diet.

元の言語英語
記事番号8397
ジャーナルScientific reports
5
DOI
出版物ステータス出版済み - 1 1 2015

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Microbiota
Bifidobacterium
Japan
Prevotella
Diet
Metagenomics
Bacteroides
Indonesia
Feeding Behavior
Thailand
Bile Acids and Salts
Taiwan
Ethnic Groups
Starch
Digestion
China
Carbohydrates
Bacteria
Gastrointestinal Microbiome

All Science Journal Classification (ASJC) codes

  • General

これを引用

Nakayama, J., Watanabe, K., Jiang, J., Matsuda, K., Chao, S. H., Haryono, P., ... Lee, Y. K. (2015). Diversity in gut bacterial community of school-age children in Asia. Scientific reports, 5, [8397]. https://doi.org/10.1038/srep08397

Diversity in gut bacterial community of school-age children in Asia. / Nakayama, Jiro; Watanabe, Koichi; Jiang, Jiahui; Matsuda, Kazunori; Chao, Shiou Huei; Haryono, Pri; La-Ongkham, Orawan; Sarwoko, Martinus Agus; Sujaya, I. Nengah; Zhao, Liang; Chen, Kang Ting; Chen, Yen Po; Chiu, Hsueh Hui; Hidaka, Tomoko; Huang, Ning Xin; Kiyohara, Chikako; Kurakawa, Takashi; Sakamoto, Naoshige; Sonomoto, Kenji; Tashiro, Kosuke; Tsuji, Hirokazu; Chen, Ming Ju; Leelavatcharamas, Vichai; Liao, Chii Cherng; Nitisinprasert, Sunee; Rahayu, Endang S.; Ren, Fa Zheng; Tsai, Ying Chieh; Lee, Yuan Kun.

:: Scientific reports, 巻 5, 8397, 01.01.2015.

研究成果: ジャーナルへの寄稿記事

Nakayama, J, Watanabe, K, Jiang, J, Matsuda, K, Chao, SH, Haryono, P, La-Ongkham, O, Sarwoko, MA, Sujaya, IN, Zhao, L, Chen, KT, Chen, YP, Chiu, HH, Hidaka, T, Huang, NX, Kiyohara, C, Kurakawa, T, Sakamoto, N, Sonomoto, K, Tashiro, K, Tsuji, H, Chen, MJ, Leelavatcharamas, V, Liao, CC, Nitisinprasert, S, Rahayu, ES, Ren, FZ, Tsai, YC & Lee, YK 2015, 'Diversity in gut bacterial community of school-age children in Asia', Scientific reports, 巻. 5, 8397. https://doi.org/10.1038/srep08397
Nakayama J, Watanabe K, Jiang J, Matsuda K, Chao SH, Haryono P その他. Diversity in gut bacterial community of school-age children in Asia. Scientific reports. 2015 1 1;5. 8397. https://doi.org/10.1038/srep08397
Nakayama, Jiro ; Watanabe, Koichi ; Jiang, Jiahui ; Matsuda, Kazunori ; Chao, Shiou Huei ; Haryono, Pri ; La-Ongkham, Orawan ; Sarwoko, Martinus Agus ; Sujaya, I. Nengah ; Zhao, Liang ; Chen, Kang Ting ; Chen, Yen Po ; Chiu, Hsueh Hui ; Hidaka, Tomoko ; Huang, Ning Xin ; Kiyohara, Chikako ; Kurakawa, Takashi ; Sakamoto, Naoshige ; Sonomoto, Kenji ; Tashiro, Kosuke ; Tsuji, Hirokazu ; Chen, Ming Ju ; Leelavatcharamas, Vichai ; Liao, Chii Cherng ; Nitisinprasert, Sunee ; Rahayu, Endang S. ; Ren, Fa Zheng ; Tsai, Ying Chieh ; Lee, Yuan Kun. / Diversity in gut bacterial community of school-age children in Asia. :: Scientific reports. 2015 ; 巻 5.
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abstract = "Asia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures and dietary habits. To address the diversity in their gut microbiota, we characterized the bacterial community in fecal samples obtained from 303 school-age children living in urban or rural regions in five countries spanning temperate and tropical areas of Asia. The microbiota profiled for the 303 subjects were classified into two enterotype-like clusters, each driven by Prevotella (P-type) or Bifidobacterium/Bacteroides (BB-type), respectively. Majority in China, Japan and Taiwan harbored BB-type, whereas those from Indonesia and Khon Kaen in Thailand mainly harbored P-type. The P-type microbiota was characterized by a more conserved bacterial community sharing a greater number of type-specific phylotypes. Predictive metagenomics suggests higher and lower activity of carbohydrate digestion and bile acid biosynthesis, respectively, in P-type subjects, reflecting their high intake of diets rich in resistant starch. Random-forest analysis classified their fecal species community as mirroring location of resident country, suggesting eco-geographical factors shaping gut microbiota. In particular, children living in Japan harbored a less diversified microbiota with high abundance of Bifidobacterium and less number of potentially pathogenic bacteria, which may reflect their living environment and unique diet.",
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AU - La-Ongkham, Orawan

AU - Sarwoko, Martinus Agus

AU - Sujaya, I. Nengah

AU - Zhao, Liang

AU - Chen, Kang Ting

AU - Chen, Yen Po

AU - Chiu, Hsueh Hui

AU - Hidaka, Tomoko

AU - Huang, Ning Xin

AU - Kiyohara, Chikako

AU - Kurakawa, Takashi

AU - Sakamoto, Naoshige

AU - Sonomoto, Kenji

AU - Tashiro, Kosuke

AU - Tsuji, Hirokazu

AU - Chen, Ming Ju

AU - Leelavatcharamas, Vichai

AU - Liao, Chii Cherng

AU - Nitisinprasert, Sunee

AU - Rahayu, Endang S.

AU - Ren, Fa Zheng

AU - Tsai, Ying Chieh

AU - Lee, Yuan Kun

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