Diversity of MHC class II DRB alleles in the Eurasian population of the least weasel, Mustela nivalis (Mustelidae: Mammalia)

Yoshinori Nishita, Pavel A. Kosintsev, Voitto Haukisalmi, Risto Väinölä, Evgeniy G. Raichev, Takahiro Murakami, Alexei V. Abramov, Yayoi Kaneko, Ryuichi Masuda

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

Mustela nivalis, the smallest member of the family Mustelidae, is widely distributed in the Holarctic region and shows high geographical variation. To further understand the molecular evolution of major histocompatibility complex (MHC), we sequenced part of MHC class II DRB gene exon 2, including codons encoding the antigen binding site (ABS), from 35 individuals from Finland, Bulgaria, Russia, and Japan. We detected 27 species-specific alleles (Muni-DRBs), some of which were broadly distributed and others geographically restricted. The ratio of nonsynonymous to synonymous substitution rates for predicted ABS codons exceeded 1, though not statistically significant. In addition, the single break point recombination (SBP) and mixed-effects model evolution (MEME) analyses demonstrated a recombination site and positive selection sites that could be committed to maintain the diversity of Muni-DRBs. In a Bayesian phylogenetic tree, all Muni-DRBs grouped within a Mustelidae clade. The Muni-DRBs showed transspecies polymorphism in related Mustela species that could have appeared to be evolved under long-lasting balancing selection. However, the sister-group patterns suggested that Mustela itatsi and Mustela sibirica alleles are much more closely related to one another than either are to M. nivalis alleles. This result correlates with the large genetic distance separating M. nivalis from M. itatsi or M. sibirica, data for which we have previously reported.

本文言語英語
ページ(範囲)28-37
ページ数10
ジャーナルBiological Journal of the Linnean Society
121
1
DOI
出版ステータス出版済み - 5 1 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生態、進化、行動および分類学

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