Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon

Takako Kikkawa, Nobuyuki Sakayori, Hayato Yuuki, Yu Katsuyama, Fumio Matsuzaki, Daijiro Konno, Takaya Abe, Hiroshi Kiyonari, Noriko Osumi

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Background: During development, Cajal-Retzius (CR) cells are the first generated and essential pioneering neurons that control neuronal migration and arealization in the mammalian cortex. CR cells are derived from specific regions within the telencephalon, that is, the pallial septum in the rostromedial cortex, the pallial-subpallial boundary, and the cortical hem (CH) in the caudomedial cortex. However, the molecular mechanism underlying the generation of CR cell subtypes in distinct regions of origin is poorly understood. Results: We found that double-sex and mab-3 related transcription factor (Dmrt) genes, that is, Dmrta1 and Dmrt3, were expressed in the progenitor domains that produce CR cells. The number of CH-derived CR cells was severely decreased in Dmrt3 mutants, especially in Dmrta1 and Dmrt3 double mutants. The reduced production of the CR cells was consistent with the developmental impairment of the CH structures in the medial telencephalon from which the CR cells are produced. Conclusion: Dmrta1 and Dmrt3 cooperatively regulate patterning of the CH structure and production of the CR cells from the CH during cortical development.

本文言語英語
ページ(範囲)698-710
ページ数13
ジャーナルDevelopmental Dynamics
249
6
DOI
出版ステータス出版済み - 6 1 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 発生生物学

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