TY - JOUR
T1 - Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon
AU - Kikkawa, Takako
AU - Sakayori, Nobuyuki
AU - Yuuki, Hayato
AU - Katsuyama, Yu
AU - Matsuzaki, Fumio
AU - Konno, Daijiro
AU - Abe, Takaya
AU - Kiyonari, Hiroshi
AU - Osumi, Noriko
N1 - Funding Information:
Financial Support for English Editing of International Research Papers in the Tohoku University Center for Gender Equality Promotion; JSPS KAKENHI, Grant/Award Numbers: 16K20902, 18K14999; MEXT Grant‐in‐Aid for Scientific Research on Innovative Areas, Grant/Award Number: 16H06530; Sasakawa Scientific Research Grant from The Japan Science Society Funding information
Funding Information:
The authors would like to thank Drs Alessandra Pierani and Tadashi Nomura for their technical advice, critical reading, and valuable comments. The authors are grateful to Ms Sayaka Makino and Yuumi Nishimura for animal care and technical support. The authors thank all other members of the Osumi laboratory for their valuable comments and discussion. The authors also thank Dr Ryuichi Shirasaki for providing an antibody and Drs Alessandra Pierani, Shinji Takada, and John Rubenstein for providing plasmids. This work was supported by a MEXT Grant‐in‐Aid for Scientific Research on Innovative Areas (#16H06530) to N.O. and by JSPS KAKENHI funding (#16K20902, #18K14999) to T.K. This work was also supported by a Sasakawa Scientific Research Grant from The Japan Science Society and Financial Support for English Editing of International Research Papers in the Tohoku University Center for Gender Equality Promotion to T.K.
Publisher Copyright:
© 2020 Wiley Periodicals, Inc.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: During development, Cajal-Retzius (CR) cells are the first generated and essential pioneering neurons that control neuronal migration and arealization in the mammalian cortex. CR cells are derived from specific regions within the telencephalon, that is, the pallial septum in the rostromedial cortex, the pallial-subpallial boundary, and the cortical hem (CH) in the caudomedial cortex. However, the molecular mechanism underlying the generation of CR cell subtypes in distinct regions of origin is poorly understood. Results: We found that double-sex and mab-3 related transcription factor (Dmrt) genes, that is, Dmrta1 and Dmrt3, were expressed in the progenitor domains that produce CR cells. The number of CH-derived CR cells was severely decreased in Dmrt3 mutants, especially in Dmrta1 and Dmrt3 double mutants. The reduced production of the CR cells was consistent with the developmental impairment of the CH structures in the medial telencephalon from which the CR cells are produced. Conclusion: Dmrta1 and Dmrt3 cooperatively regulate patterning of the CH structure and production of the CR cells from the CH during cortical development.
AB - Background: During development, Cajal-Retzius (CR) cells are the first generated and essential pioneering neurons that control neuronal migration and arealization in the mammalian cortex. CR cells are derived from specific regions within the telencephalon, that is, the pallial septum in the rostromedial cortex, the pallial-subpallial boundary, and the cortical hem (CH) in the caudomedial cortex. However, the molecular mechanism underlying the generation of CR cell subtypes in distinct regions of origin is poorly understood. Results: We found that double-sex and mab-3 related transcription factor (Dmrt) genes, that is, Dmrta1 and Dmrt3, were expressed in the progenitor domains that produce CR cells. The number of CH-derived CR cells was severely decreased in Dmrt3 mutants, especially in Dmrta1 and Dmrt3 double mutants. The reduced production of the CR cells was consistent with the developmental impairment of the CH structures in the medial telencephalon from which the CR cells are produced. Conclusion: Dmrta1 and Dmrt3 cooperatively regulate patterning of the CH structure and production of the CR cells from the CH during cortical development.
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U2 - 10.1002/dvdy.156
DO - 10.1002/dvdy.156
M3 - Article
C2 - 32012381
AN - SCOPUS:85079408778
SN - 1058-8388
VL - 249
SP - 698
EP - 710
JO - American Journal of Anatomy
JF - American Journal of Anatomy
IS - 6
ER -