DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

Pengju Pan, Masahiro Fujita, Wei Yang Ooi, Kumar Sudesh, Tohru Takarada, Atsushi Goto, Mizuo Maeda

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

抄録

Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.

元の言語英語
ページ(範囲)895-900
ページ数6
ジャーナルPolymer
52
発行部数4
DOI
出版物ステータス出版済み - 2 17 2011

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Atom transfer radical polymerization
DNA
Copolymers
Single-Stranded DNA
Micelles
Stars
Temperature
Molecules

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics

これを引用

DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry. / Pan, Pengju; Fujita, Masahiro; Ooi, Wei Yang; Sudesh, Kumar; Takarada, Tohru; Goto, Atsushi; Maeda, Mizuo.

:: Polymer, 巻 52, 番号 4, 17.02.2011, p. 895-900.

研究成果: ジャーナルへの寄稿記事

Pan, Pengju ; Fujita, Masahiro ; Ooi, Wei Yang ; Sudesh, Kumar ; Takarada, Tohru ; Goto, Atsushi ; Maeda, Mizuo. / DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry. :: Polymer. 2011 ; 巻 52, 番号 4. pp. 895-900.
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abstract = "Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.",
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AU - Goto, Atsushi

AU - Maeda, Mizuo

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