DNA typing of HLA‐B gene in Takayasu's Arteritis

Masayuki Yoshida, Akineri Kimura, Kiyanari Katsuragi, Fujia Numano, Takohlko Sasazuki

研究成果: Contribution to journalArticle査読

66 被引用数 (Scopus)

抄録

Abstract: Sixty‐four patients with Takayasu's arteritis and 156 healthy individuals in the Japanese population were examined for HLA‐B specificity at the DNA level by DNA typing using polymerase chain reaction (PCR)/sequence‐specific oligonucleotide probe (SSOP) analysis and by subsequent sequencing analysis. The frequency of epitope combination group‐B52 (EC‐B52) corresponding precisely to HLA‐B52 specificity and that of EC‐B39.2 which is a newly‐identified subtype of HLA‐B39 specificity were increased in the patient group. These two disease‐associated HLA‐B alleles share an epitope composed of 63Glu and 67Ser. Because two HLA‐B alleles, HLA‐B51 and B39.1, which are similar but different at the epitope from HLA‐B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis. 1993 Blackwell Munksgaard

本文言語英語
ページ(範囲)87-90
ページ数4
ジャーナルTissue antigens
42
1
DOI
出版ステータス出版済み - 7 1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 生化学
  • 遺伝学

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