Does Down syndrome affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life?

Munetaka Masuda, Hideaki Kado, Yoshihisa Tanoue, Koji Fukae, Tatsushi Onzuka, Yuichiro Shiokawa, Toshihiko Shirota, Hisataka Yasui

研究成果: ジャーナルへの寄稿学術誌査読

37 被引用数 (Scopus)

抄録

Background: Down syndrome is known to affect the natural history of complete atrioventricular septal defect. We analyzed whether Down syndrome affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life. Methods: Repairs of complete atrioventricular septal defect were performed in 64 infants. Thirty-four infants were associated with Down syndrome, while the other 30 were non-Down patients. Results: Complete follow-up rate was 95% with mean follow-up period of 99±47 months (maximum 169 months) in Down patients and 80±64 months (maximum 213 months) in non-Down patients. There was one operative death in each group (mortality rate of 2.9% in Down patients and 3.3% in non-Down patients), and three patients died at the late phase (one in Down patients and two in non-Down patients). Five patients underwent re-operation due to postoperative left atrioventricular valve regurgitation (one in Down patients and four in non-Down patients). Freedom from re-operation for left atrioventricular valve regurgitation and actuarial survival rate at 13 years were 96±4 and 94±4% in Down patients and 85±7 and 90±5% in non-Down patients (not significantly different). Conclusions: Down syndrome does not affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life.

本文言語英語
ページ(範囲)405-409
ページ数5
ジャーナルEuropean Journal of Cardio-thoracic Surgery
27
3
DOI
出版ステータス出版済み - 3月 2005

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学

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