Does Down syndrome affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life?

Munetaka Masuda, Hideaki Kado, Yoshihisa Tanoue, Koji Fukae, Tatsushi Onzuka, Yuichiro Shiokawa, Toshihiko Shirota, Hisataka Yasui

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Background: Down syndrome is known to affect the natural history of complete atrioventricular septal defect. We analyzed whether Down syndrome affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life. Methods: Repairs of complete atrioventricular septal defect were performed in 64 infants. Thirty-four infants were associated with Down syndrome, while the other 30 were non-Down patients. Results: Complete follow-up rate was 95% with mean follow-up period of 99±47 months (maximum 169 months) in Down patients and 80±64 months (maximum 213 months) in non-Down patients. There was one operative death in each group (mortality rate of 2.9% in Down patients and 3.3% in non-Down patients), and three patients died at the late phase (one in Down patients and two in non-Down patients). Five patients underwent re-operation due to postoperative left atrioventricular valve regurgitation (one in Down patients and four in non-Down patients). Freedom from re-operation for left atrioventricular valve regurgitation and actuarial survival rate at 13 years were 96±4 and 94±4% in Down patients and 85±7 and 90±5% in non-Down patients (not significantly different). Conclusions: Down syndrome does not affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life.

元の言語英語
ページ(範囲)405-409
ページ数5
ジャーナルEuropean Journal of Cardio-thoracic Surgery
27
発行部数3
DOI
出版物ステータス出版済み - 3 2005

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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