抄録
Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 291-294 |
| ページ数 | 4 |
| ジャーナル | Journal of Pharmacological Sciences |
| 巻 | 140 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 7 1 2019 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
これを引用
Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect. / kawashiri, takehiro; Shimizu, Shiori; Shigematsu, Nao; Kobayashi, Daisuke; Shimazoe, Takao.
：: Journal of Pharmacological Sciences, 巻 140, 番号 3, 01.07.2019, p. 291-294.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect
AU - kawashiri, takehiro
AU - Shimizu, Shiori
AU - Shigematsu, Nao
AU - Kobayashi, Daisuke
AU - Shimazoe, Takao
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.
AB - Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.
UR - http://www.scopus.com/inward/record.url?scp=85069946078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069946078&partnerID=8YFLogxK
U2 - 10.1016/j.jphs.2019.05.009
DO - 10.1016/j.jphs.2019.05.009
M3 - Article
C2 - 31377017
AN - SCOPUS:85069946078
VL - 140
SP - 291
EP - 294
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 3
ER -