Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

takehiro kawashiri, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao Shimazoe

研究成果: Contribution to journalArticle

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Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.

元の言語英語
ページ(範囲)291-294
ページ数4
ジャーナルJournal of Pharmacological Sciences
140
発行部数3
DOI
出版物ステータス出版済み - 7 1 2019

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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