Doubly N-Confused Calix[6]phyrin Bis-Organopalladium Complexes: Photostable Triplet Sensitizers for Singlet Oxygen Generation

Poornenth Pushpanandan, Dong Hoon Won, Shigeki Mori, Yuhsuke Yasutake, Susumu Fukatsu, Masatoshi Ishida, Hiroyuki Furuta

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Triplet photosensitizers that generate singlet oxygen efficiently are attractive for applications such as photodynamic therapy (PDT). Extending the absorption band to a near-infrared (NIR) region (700 nm≈) with reasonable photostability is one of the major demands in the rational design of such sensitizers. We herein prepared a series of mono- and bis-palladium complexes (1-Pd-H 2 , 2-Pd-H 2 , 1-Pd-Pd, and 2-Pd-Pd) based on modified calix[6]phyrins as photosensitizers for singlet oxygen generation. These palladium complexes showed intense absorption profiles in the visible-to-NIR region (500–750 nm) depending on the number of central metals. Upon photoirradiation in the presence of 1,5-dihydroxynaphthalene (DHN) as a substrate for reactive oxygen species, the bis-palladium complexes generated singlet oxygen with high efficiency and excellent photostability. Singlet oxygen generation was confirmed from the characteristic spectral feature of the spin trapped complex in the EPR spectrum and the intact 1 O 2 emission at 1270 nm.

元の言語英語
ページ(範囲)1729-1736
ページ数8
ジャーナルChemistry - An Asian Journal
14
発行部数10
DOI
出版物ステータス出版済み - 5 15 2019

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Singlet Oxygen
Palladium
Photosensitizing Agents
Infrared radiation
Photodynamic therapy
Photochemotherapy
Paramagnetic resonance
Absorption spectra
Reactive Oxygen Species
Metals
calix(6)phyrin
Substrates

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Organic Chemistry

これを引用

Doubly N-Confused Calix[6]phyrin Bis-Organopalladium Complexes : Photostable Triplet Sensitizers for Singlet Oxygen Generation. / Pushpanandan, Poornenth; Won, Dong Hoon; Mori, Shigeki; Yasutake, Yuhsuke; Fukatsu, Susumu; Ishida, Masatoshi; Furuta, Hiroyuki.

:: Chemistry - An Asian Journal, 巻 14, 番号 10, 15.05.2019, p. 1729-1736.

研究成果: ジャーナルへの寄稿記事

Pushpanandan, Poornenth ; Won, Dong Hoon ; Mori, Shigeki ; Yasutake, Yuhsuke ; Fukatsu, Susumu ; Ishida, Masatoshi ; Furuta, Hiroyuki. / Doubly N-Confused Calix[6]phyrin Bis-Organopalladium Complexes : Photostable Triplet Sensitizers for Singlet Oxygen Generation. :: Chemistry - An Asian Journal. 2019 ; 巻 14, 番号 10. pp. 1729-1736.
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abstract = "Triplet photosensitizers that generate singlet oxygen efficiently are attractive for applications such as photodynamic therapy (PDT). Extending the absorption band to a near-infrared (NIR) region (700 nm≈) with reasonable photostability is one of the major demands in the rational design of such sensitizers. We herein prepared a series of mono- and bis-palladium complexes (1-Pd-H 2 , 2-Pd-H 2 , 1-Pd-Pd, and 2-Pd-Pd) based on modified calix[6]phyrins as photosensitizers for singlet oxygen generation. These palladium complexes showed intense absorption profiles in the visible-to-NIR region (500–750 nm) depending on the number of central metals. Upon photoirradiation in the presence of 1,5-dihydroxynaphthalene (DHN) as a substrate for reactive oxygen species, the bis-palladium complexes generated singlet oxygen with high efficiency and excellent photostability. Singlet oxygen generation was confirmed from the characteristic spectral feature of the spin trapped complex in the EPR spectrum and the intact 1 O 2 emission at 1270 nm.",
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