Drebrin is induced during myofibroblast differentiation and enhances the production of fibrosis-related genes

Takanori Hironaka, Tomoyuki Ueno, Kyosuke Mae, Chikashi Yoshimura, Takumi Morinaga, Yuma Horii, Akiomi Nagasaka, Hitoshi Kurose, Michio Nakaya

研究成果: Contribution to journalArticle

抜粋

Fibrosis is attributed to excess deposition of extracellular matrix (ECM) proteins including collagen and is associated with various organ dysfunction. This excessive ECM is produced by myofibroblasts, which are differentiated from various cells by a variety of stimuli, represented by TGF-β. However, molecular mechanisms for the regulation of ECM production in myofibroblasts remain obscure. In this study, we demonstrate that the expression of drebrin, which binds to and increases the stability of actin filament in neurons, is increased in mouse hearts and lungs upon fibrosis. Drebrin is mainly expressed in myofibroblasts in the fibrotic hearts and lungs and promotes the expression of fibrosis-related genes, such as Acta2 and Col1a1. Taken together, our study identifies drebrin as a molecule that promotes the production of fibrosis-related genes in myofibroblasts.

元の言語英語
ページ(範囲)224-230
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
529
発行部数2
DOI
出版物ステータス出版済み - 8 20 2020

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント Drebrin is induced during myofibroblast differentiation and enhances the production of fibrosis-related genes' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用