Drug interactions of zonisamide with phenytoin and sodium valproate: serum concentrations and protein binding

Kohsuke Tasaki, Taketsugu Minami, Ichiro Ieiri, Kenji Ohtsubo, Yoshihiro Hirakawa, Kohji Ueda, Shun Higuchi

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

The influence of co-medication with zonisamide (ZNS) on the serum concentration and protein binding of phenytoin (PHT) and sodium valproate (VPA) was studied in 21 pediatric patients. No significant correlation between the daily ZNS dose, and total serum concentrations, free concentrations or free fractions (FF) of PHT or VPA was observed. The patient study showed that changes in the FF of PHT and VPA were correlated more closely with the serum protein and bilirubin levels than changes in the ZNS dosage. An in vitro study revealed that the addition of ZNS caused decreases in the FF of PHT and VPA. However, these decreases were within the range of measurement error and were negligible. In conclusion, no significant effect of ZNS on the serum concentration or protein binding of PHT or VPA was demonstrated.

本文言語英語
ページ(範囲)182-185
ページ数4
ジャーナルBrain and Development
17
3
DOI
出版ステータス出版済み - 1995

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 発達神経科学
  • 臨床神経学

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