@article{25828ba5e664461ab27a5e8bf67dc247,
title = "Dynamic behavior of cyclic enzyme systems",
abstract = "The dynamic behavior of cyclic enzyme systems where two enzymes share a substrate or cofactor in a cyclic manner is investigated by computer simulation. The dynamic characteristics of cyclic enzyme systems display catastrophic behavior in response to specific changes in external input without assuming allosteric regulation.",
author = "Masahiro Okamoto and Katsuya Hayashi",
note = "Funding Information: This work was supported by a grant of scientific research from the Ministry of Education, Japan. The authors would like to thank Professor Dr Helmut Holzer at Albert-Ludwigs-Universit5.t who critically read and made precious comments to this study. The authors also acknowledge Professor Dr Robert Rosen at Dalhousie University who considerably improved this manuscript.",
year = "1983",
month = oct,
day = "21",
doi = "10.1016/0022-5193(83)90247-3",
language = "English",
volume = "104",
pages = "591--598",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "Academic Press Inc.",
number = "4",
}